Références Scientifiques

La forme la plus pure du marché garantie à plus de 99 % d’acide L-ascorbique.

7, place de l’ancien foirail – 32410 Castéra-Verduzan – Gers – Gascogne
Siret 510 217 326 00014 – Code APE 4729Z
Tél. : 05.62.68.02.05 du lundi au vendredi de 10 h à 18 h 30 ou vitcnat@free.fr

RÉFÉRENCES SCIENTIFIQUES SUR LA VITAMINE C

Ascorbic acide (acide ascorbique) = L-ascorbic acid (acide L-ascorbique) = vitamin C (vitamine C), ascorbate = vitamine C tamponnée

Mentions légales : toutes les informations fournies dans ce site proviennent d’autres sources fiables rédigées par des professionnels de santé ou des personnes qualifiées. Ces informations sont présentées de manière non-exhaustive et sont diffusées essentiellement dans un but d’information générale et ne sont pas destinées à remplacer la consultation d’un professionnel de la santé. Vous ne devez en aucun cas utiliser les informations contenues dans ce site pour établir un diagnostic ou déterminer un traitement. Ces informations sont fournies uniquement à titre instructif et ne visent pas à diagnostiquer, traiter ou guérir des maladies.

Abbasy, M., N. Hill, M. Lond, and L. Harris. (1936) Vitamin C and juvenile rheumatism with some observations on the vitamin-C reserves in surgical tuberculosis. The Lancet 2:1413-1417.

Abbasy, M., L. Harris, and P. Ellman. (1937) Vitamin C and infection. Excretion of vitamin C in pulmonary tuberculosis and in rheumatoid arthritis. The Lancet 2:181-183.

Adam-Vizi, V., G. Varadi, and P. Simon. (1981) Reduction of vanadate by ascorbic acid and noradrenaline in synaptosomes. Journal of Neurochemistry 36(5):1616-1620.

Ademuyiwa, O., O. Adesanya, and O. Ajuwon. (1994) Vitamin C in CCl4 hepatotoxicity-a preliminary report. Human & Experimental Toxicology 13(2):107-109.

Agrawal, N., C. Juneja, and C. Mahajan. (1978) Protective role of ascorbic acid in fishes exposed to organochlorine pollution. Toxicology 11(4):369-375.

Alabi, Z., K. Thomas, O. Ogunbona, and I. Elegbe. (1994) The effect of antibacterial agents on plasma vitamin C levels. African Journal of Medicine and Medical Sciences 23(2):143-146.

Ala-Ketola, L., R. Varis, and K. Kiviniitty. (1974) Effect of ascorbic acid on the survival of rats after whole body irradiation. Strahlentherapie 148(6):643-644.

Aldashev, A., T. Igumnova, and G. Servetnik-Chalaia. (1980) [Effect of benzene and its homologues on body ascorbic acid allowance under prolonged C vitaminization]. Article in Russian. Voprosy Pitaniia 1:38-41.

Aleo, J. (1980) Inhibition of endotoxin-induced depression of cellular proliferation by ascorbic acid. Proceedings of the Society for Experimental Biology and Medicine 164(3):248-251.

Aleo, J. and H. Padh. (1985) Inhibition of ascorbic acid uptake by endotoxin: evidence of mediation by serum factor(s). Proceedings of the Society for Experimental Biology and Medicine 179(1):128-131.

Alessio, H., A. Goldfarb, and G. Cao. (1997) Exercise-induced oxidative stress before and after vitamin C supplementation. International Journal of Sport Nutrition 7(1):1-9.

Albrecht, E. (1938) Vitamin C as an adjuvant in the therapy of lung tuberculosis. Medizinische Klinic (Munchen) 34:972-973.

Allard, J., E. Aghdassi, J. Chau, C. Tarn, C. Kovacs, I. Salit, and S. Walmsley. (1998) Effects of vitamin E and C supplementation on oxidative stress and viral load in HIV infected subjects. AIDS 12(13):1653-1659.

Altmann, P., R. Maruna, H. Maruna, W. Michalica, and G. Wagner. (1981) [Lead detoxication effect of a combined calcium phosphate and ascorbic acid therapy in pregnant women with increased lead burden]. German. Wiener Medizinische Wochenschrift 131(12):311-314.

Amato, G. (1937) Azione dell’acido ascorbico sul virus fisso della rabbia e sulla tossina tetanica. Giornale di Batteriologia, Virologia et Immunologia (Torino) 19:843-847.

Andersen, R. and O. Dittrich. (1979) Effects of ascorbate on leucocytes. Part IV. Increased neutrophil function and clinical improvement after oral ascorbate in 2 patients with chrome granulomatous disease. South African Medical Journal 56(12):476-480.

Anderson, R. and A. Theron. (1979) Effects of ascorbate on leucocytes. Part III. In vitro and in vivo stimulation of abnormal neutrophil motility by ascorbate. South African Medical Journal 56(11):429-433.

Anderson, R., R. Oosthuizen, R. Maritz, A. Theron, and A. Van Rensburg. (1980) The effects of increasing weekly doses of ascorbate on certain cellular and humoral immune functions in normal volunteers. The American Journal of Clinical Nutrition 33(1): 71-76.

Anderson, R., I. Hay, H. van Wyk, R. Oosthuizen, and A. Theron. (1980a) The effect of ascorbate on cellular humoral immunity in asthmatic children. South African Medical Journal 58(24):974-977.

Anderson, D., B. Phillips, T. Yu, A. Edwards, R. Ayesh, and K. Butterworth. (1997) The effects of vitamin C supplementation on biomarkers of oxygen radical generated damage in human volunteers with « low » or « high » cholesterol levels. Environmental and Molecular Mutagenesis 30(2):161-174.

Andreasen, C. and D. Frank. (1999) The effects of ascorbic acid on in vitro heterophil function. Avian Diseases 43(4):656-663.

Anane, R. and E. Creppy. (2001) Lipid peroxidation as pathway of aluminium cytotoxicity in human skin fibroblast cultures: prevention by superoxide dismutase+catalase and vitamins E and C. Human & Experimental Toxicology 20(9):477-481.

Antunes, L. and C. Takahashi. (1998) Effects of high doses of vitamins C and E against doxorubicin-induced chromosomal damage in Wistar rat bone marrow cells. Mutation Research 419(1-3):137-143.

Appenroth, D., S. Frob, L. Kersten, F. Splinter, and K. Winnefeld. (1997) Protective effects of vitamin E and C on cisplatin nephrotoxicity in developing rats. Archives of Toxicology 71(11): 677-683.

Appenroth, D. and K. Winnefeld. (1998) Vitamin E and C in the prevention of metal nephrotoxicity in developing rats. Experimental and Toxicologie Pathology 50(4-6):391-396.

Atkinson, J., A. Weiss, M. Ito, J. Kelly, and C. Parker. (1979) Effects of ascorbic acid and sodium ascorbate on cyclic nucleotide metabolism in human lymphocytes. Journal of Cyclic Nucleotide Research 5(2):107-123.

Auer, B., D. Auer, and A. Rodgers. (1998) Relative hyperoxaluria, crystalluria and haematuria after megadose ingestion of vitamin C. European Journal of Clinical Investigation 28(9):695-700.

Auer, B., D. Auer, and A. Rodgers. (1998a) The effect of ascorbic acid ingestion on the biochemical and physicochemical risk factors associated with calcium oxalate kidney stone formation. Clinical Chemistry and Laboratory Medicine 36(3): 143-147.

Awotedu, A., E. Sofowora, and S. Ette. (1984) Ascorbic acid deficiency in pulmonary tuberculosis. East African Medical Journal 61(4):283-287.

Axelrod, J., S. Udenfriend, and B. Brodie. (1954) Ascorbic acid in aromatic hydroxylation. III. Effect of ascorbic acid on hydroxylation of acetanilide, aniline and antipyrine in vivo. The Journal of Pharmacology and Experimental Therapeutics 111:176-181.

Babbar, I. (1948) Observations of ascorbic acid. Part XI. Therapeutic effect of ascorbic acid in tuberculosis. The Indian Medical Gazette 83:409-410.

Baker, E., R. Hodges, J. Hood, H. Sauberlich, S. March, and J. Canham. (1971) Metabolism of 14-C and 3-H-labeled L-ascorbic acid in human scurvy. The American Journal of Clinical Nutrition 24(4):444-454.

Baetgen, D. (1961) [Results of the treatment of epidemic hepatitis in children with high doses of ascorbic acid in the years 1957-1958]. German. Medizinische Monatschrift 15:30-36.

Bakhsh, I. and M. Rabbani. (1939) Vitamin C in pulmonary tuberculosis. The Indian Medical Gazette 74:274-277.

Banerjee, S., P. Sen, and B. Guha. (1940) Urinary excretion of combined ascorbic acid in pulmonary tuberculosis. Nature 145(3679):706-707.

Banic, S. (1975) Prevention of rabies by vitamin C. Nature 258(5531):153-154.

Banic, S. (1982) Immunostimulation by vitamin C. International Journal for Vitamin and Nutrition Research. Supplement 23:49-52.

Baur, H. (1952) [Poliomyelitis therapy with ascorbic acid]. German. Helvetia Medica Acta 19:470-474.

Baur, H. and H. Staub. (1954) [Therapy of hepatitis with ascorbic acid infusions]. Article in German. Schweizerische Medizinische Wochenschrift 84:595-597.

Bachleitner-Hofmann, T., B. Gisslinger, E. Grumbeck, and H. Gisslinger. (2001) Arsenic trioxide and ascorbic acid: synergy with potential implications for the treatment of acute myeloid leukaemia? British Journal of Haematology 112(3):783-786.

Balcke, P., P. Schmidt, J. Zazgornik, H. Kopsa, and A. Haubenstock. (1984) Ascorbic acid aggravates secondary hyperoxalemia in patients on chronic hemodialysis. Annals of Internal Medicine 101(3):344-345.

Barja, G., M. Lopez-Torres, R. Perez-Campo, C. Rojas, S. Cadenas, J. Prat, and R. Pamplona. (1994) Dietary vitamin C decreases endogenous protein oxidative damage, malondialdehyde, and lipid peroxidation and maintains fatty acid unsaturation in the guinea pig liver. Free Radical Biology & Medicine 17(2):105-115.

Bandyopadhyay, S., R. Tiwari, A. Mitra, B. Mukherjee, A. Banerjee, and G. Chatterjee. (1982) Effects of L-ascorbic acid supplementation on dieldrin toxicity in rats. Archives of Toxicology 50(3-4):227-232.

Banerjee, S. and P. Basu. (1975) Ascorbic acid metabolism in mice treated with tetracyclines & chloramphenicol. Indian Journal of Experimental Biology 13(6)567-569.

Bass, W., N. Malati, M. Castle, and L. White. (1998) Evidence for the safety of ascorbic acid administration to the premature infant. American Journal of Perinatology 15(2):133-140.

Basu, S., S. Som, S. Deb, D. Mukherjee, and I. Chatterjee. (1979) Dehydroascorbic acid reduction in human erythrocytes. Biochemical and Biophysical Research Communications 90(4):1335-1340.

Basu, T. (1977) Possible toxicological aspects of megadoses of ascorbic acid. Chemico-Biological Interactions 16(2):247-250.

Basu, T. (1983) High-dose ascorbic acid decreases detoxification of cyanide derived from amygdalin (laetrile): studies in guinea pigs. Canadian Journal of Physiology and Pharmacology 61(11):1426-1430.

Bechelli, L. (1939) Vitamin C therapy of the lepra reaction. Revista Brasileira de Leprologia (Sao Paulo) 7:251-255.

Belfield, W. (1967) Vitamin C in treatment of canine and feline distemper complex. Veterinary Medicine/Small Animal Clinician 62(4):345-348.

Belfield, W. and I. Stone. (1975) Megascorbic prophylaxis and megascorbic therapy: a new orthomolecular modality in veterinary medicine. Journal of the International Academy of Preventive Medicine 2:10-26.

Bell, J., C. Beglan, and E. London. (1996) Interaction of ascorbic acid with the neurotoxic effects of NMDA and sodium nitroprusside. Life Sciences 58(4):367-371.

Benabdeljelil, K. and L. Jensen. (1990) Effectiveness of ascorbic acid and chromium in counteracting the negative effects of dietary vanadium on interior egg quality. Poultry Science 69(5):781-786.

Benito, B., D. Wahl, N. Steudel, A. Cordier, and S. Steiner. (1995) Effects of cyclosporine A on the rat liver and kidney protein pattern, and the influence of vitamin E and C coadministration. Electrophoresis 16(7):1273-1283.

Benito, E. and M. Bosch. (1997) Impaired phosphatidylcholine biosynthesis and ascorbic acid depletion in lung during lipopolysaccharide-induced endotoxaemia in guinea pigs. Molecular and Cellular Biochemistry 175(1-2):117-123.

Beyer, K. (1943) Protective action of vitamin C against experimental hepatic damage. Archives of Internal Medicine 71:315-324.

Bendich, A. and L. Langseth. (1995) The health effects of vitamin C supplementation: a review. Journal of the American College of Nutrition l4(2):124-136.

Berger, T., M. Polidori, A. Dabbagh, P. Evans, B. Halliwell, J. Morrow, L. Roberts, and B. Frei. (1997) Antioxidant activity of vitamin C in iron-overloaded human plasma. The Journal of Biological Chemistry 272(25):15656-15660.

Bhaduri, J. and S. Banerjee. (1960) Ascorbic acid, dehydro-ascorbic acid and glutathione levels in blood of patients suffering from infectious diseases. The Indian Journal of Medical Research 48:208-211.

Birkhaug, K. (1938) The role of vitamin C in the pathogenesis of tuberculosis in the guinea-pig. I. Daily excretion of vitamin C in urine of L-ascorbic acid treated and control tuberculous animals. II. Vitamin C content of suprarenals of L-ascorbic acid treated and control tuberculous animals. Acta Tuberculosea Scandinavica 12:89-104.

(1938) III. Quantitative variations in the haemogram of L-ascorbic acid treated and control tuberculous animals. Acta Tuberculosea Scandinavica 12:359-372.

(1939) IV. Effect of L-ascorbic acid on the tuberculin reaction in tuberculous animals. Acta Tuberculosea Scandinavica 13:45-51.

(1939) V. Degree of tuberculosis in L-ascorbic acid treated and control tuberculosis animals. Acta Tuberculosea Scandinavica 13:52-66.

Blondin, J., V. Baragi, E. Schwartz, J. Sadowski, and A. Taylor. (1986) Delay of UV-induced eye lens protein damage in guinea pigs by dietary ascorbate. Journal of Free Radicals in Biology & Medicine 2(4):275-281.

Blackstone, S., R. Hurley, and R. Hughes. (1974) Some inter-relationships between vitamin C (L-ascorbic acid) and mercury in the guinea-pig. Food and Cosmetics Toxicology 12(4)511-516.

Blanco, O. and T. Meade. (1980) Effect of dietary ascorbic acid on the susceptibility of steelhead trout (Salmo gairdneri) to nitrite toxicity. Revista de Biologia Tropical 28(1):91-107.

Blankenship, L., D. Carlisle, J. Wise, J. Orenstein, L. Dye, and S. Patierno. (1997) Induction of apoptotic cell death by particulate lead chromate: differential effects of vitamins C and E on genotoxicity and survival. Toxicology and Applied Pharmacology 146(2):270-280.

Blasiak, J. and J. Kowalik. (2001) Protective action of vitamin C against DNA damage induced by selenium-cisplatin conjugate. Acta Biochimica Polonica 48(1):233-240.

Blasiak, J., M. Kadlubek, J. Kowalik, H. Romanowicz-Makowska, and T. Pertynski. (2002) Inhibition of telomerase activity in endometrial cancer cells by selenium-cisplatin conjugate despite suppression of its DNA-damaging activity by sodium ascorbate. Teratogenesis, Carcinogenesis, and Mutagenesis 22(l):73-82.

Bode, A., C. Yavarow, D. Fry, and T. Vergas. (1993) Enzymatic basis for altered ascorbic acid and dehydroascorbic acid levels in diabetics. Biochemical and Biophysical Research Communications 191(3):1347-1353.

Bogen, E., L. Hawkins, and E. Bennett. (1941) Vitamin C treatment of mucous membrane tuberculosis. American Review of Tuberculosis 44:596-603.

Borsalino, G. (1937) La fragilita capillare nella tubercolosi polmonare e le sue modificazioni per azione della vitamin C. Giornale di Clinica Medica (Bologna) 18:273-294.

Bossevain, C. and J. Spillane. (1937) A note on the effect of synthetic ascorbic acid (vitamin C) on the growth of the tubercle bacillus. American Review of Tuberculosis 35:661-662.

Boura, P., G. Tsapas, A. Papadopoulou, I. Magoula, and G. Kountouras. (1989) Monocyte locomotion in anergic chronic brucellosis patients: the in vivo effect of ascorbic acid. Immunopharmacology and Immunotoxicology 11(1):119-129.

Bourke, G., R. Coleman, and N. Rencricca. (1980) Effect of ascorbic acid on host resistance in virulent rodent malaria. Clinical Research 28(3):642A.

Bourne, G. (1949) Vitamin C and immunity. The British Journal of Nutrition 2:342.

Boyden, S. and M. Andersen. (1956) Diet and experimental tuberculosis in the guinea pig. The importance of the source of ascorbic acid. Acta Pathologica et Microbiologica Scandinavica 39:107-116.

Boxer, L., A. Watanabe, M. Rister, H. Besch, J. Allen, and R. Baehner. (1976) Correction of leukocyte function in Chediak-Higashi syndrome by ascorbate. The New England Journal of Medicine 295(19):1041-1045.

Boxer, L., B. Vanderbilt, S. Bonsib, R. Jersild, H. Yang, and R. Baehner. (1979) Enhancement of chemotactic response and microtubule assembly in human leukocytes by ascorbic acid. Journal of Cellular Physiology 100(1):119-126.

Bohm, F, R. Edge, D. McGarvey, and T. Truscott. (1998) Beta-carotene with vitamins E and C offers synergistic cell protections against NOx. FEBS Letters 436(3):387-389.

Bolyai, J., R. Smith, and C. Gray. (1972) Ascorbic acid and chemically induced methemoglobinemias. Toxicology and Applied Pharmacology 21(2):176-185.

Bose, S. and S. Sinha. (1994) Modulation of ochratoxin-produced genotoxicity in mice by vitamin C. Food and Chemical Toxicology 32(6)533-537.

Brissot, P., Y. Deugnier, A. Le Treut, F. Regnouard, M. Simon, and M. Bourel. (1978) Ascorbic acid status in idiopathic hemochromatosis. Digestion 17(6):479-487.

Bradberry, S. and J. Vale. (1999) Therapeutic review: is ascorbic acid of value in chromium poisoning and chromium dermatitis? Journal of Toxicology. Clinical Toxicology 37(2):195-200.

Brox, A., K. Howson-Jan, and A. Fauser. (1988) Treatment of idiopathic thrombocytopenic purpura with ascorbate. British Journal of Haematology 70(3):341-344.

Buettner, G. and B. Jurkiewicz. (1996) Catalytic metals, ascorbate and free radicals: combinations to avoid. Radiation Research 145(5):532-541.

Bundesen, H., H. Aron, R. Greenebaum, C. Farmer, and A. Abt. (1941) The detoxifying action of vitamin C (ascorbic acid) in arsenical therapy. I. Ascorbic acid as a preventive of reactions of human skin to neoarsphenamine. The Journal ofthe American Medical Association 117(20):1692-1695.

Busnel, R. and A. Lehmann. (1980) Antagonistic effect of sodium ascorbate on ethanol-induced changes in swimming of mice. Behavioural Brain Research l(4):351-356.

Burkitt, M. and B. Gilbert. (1990) Model studies of the iron-catalysed Haber-Weiss cycle and the ascorbate-driven Fenton reaction. Free Radical Research Communications 10(4-5):265-280.

Bumbalo, T. (1938) Urinary output of vitamin C of normal and of sick children. With a laboratory test for its estimation. American Journal of Diseases of Children 55:1212-1220.

Bumbalo, T. and W. Jetter. (1938) Vitamin C in tuberculosis. The effect of supplementary synthetic vitamin C on the urinary output of this vitamin by tuberculous children. The Journal of Pediatrics 13:334-340.

Burns, J., H. Burch, and C. King. (1951) The metabolism of 1-C14-L-ascorbic acid in guinea pigs. The Journal of Biological Chemistry 191:501.

Bussey, H., J. DeCosse, E. Deschner, A. Eyers, M. Lesser, B. Morson, S. Ritchie, J. Thomson, and J. Wadsworth. (1982) A randomized trial of ascorbic acid in polyposis coli. Cancer 50(7):1434-1439.

Cadenas, S., C. Rojas, and G. Barja. (1998) Endotoxin increases oxidative injury to proteins in guinea pig liver: protection by dietary vitamin C. Pharmacology & Toxicology 82(l):11-18.

Calleja, H. and R. Brooks. (1960) Acute hepatitis treated with high doses of vitamin C. The Ohio State Medical Journal 56:821-823.

Campbell, J., M. Cole, B. Bunditrutavorn, and A. Vella. (1999) Ascorbic acid is a potent inhibitor of various forms of T cell apoptosis. Cellular Immunology 194(l):l-5.

Carlsson, S., N. Wiklund, L. Engstrand, E. Weitzberg, and J. Lundberg. (2001) Effects of pH, nitrite, and ascorbic acid on nonenzymatic nitric oxide generation and bacterial growth in urine. Nitric Oxide: Biology and Chemistry 5(6)580-586.

Carr, A., R. Einstein, L. Lai, N. Martin, and G. Starmer. (1981) Vitamin C and the common cold: using identical twins as controls. The Medical Journal of Australia 2(8):411-412.

Cadenas, S., S. Lertsiri, M. Otsuka, B. Barja, and T. Miyazawa. (1996) Phospholipid hydroperoxides and lipid peroxidation in liver and plasma of ODS rats supplemented with alpha-tocopherol and ascorbic acid. Free Radical Research 24(6):485-493.

Cadenas, S., G. Barja, H. Poulsen, and S. Loft. (1997) Oxidative DNA damage estimated by oxo8dG in the liver of guinea-pigs supplemented with graded dietary doses of ascorbic acid and alpha-tocopherol. Carcinogenesis 18(12):2373-2377.

Cadenas, S., C. Rojas, and G. Barja. (1998) Endotoxin increases oxidative injury to proteins in guinea pig liver: protection by dietary vitamin C. Pharmacology & Toxicology 82(1):11-18.

Calabrese, E. (1979) Conjoint use of laetrile and megadoses of ascorbic acid in cancer treatment: possible side effects. Medical Hypotheses 5(9):995-997.

Calabrese, E., G. Moore, and M. McCarthy. (1983) Effect of ascorbic acid on copper-induced oxidative changes in erythrocytes of individuals with a glucose-6-phosphate dehydrogenase deficiency. Bulletin of Environmental Contamination and Toxicology 30(3):323-330.

Campbell, A. and T. Jack. (1979) Acute reactions to mega ascorbic acid therapy in malignant disease. Scottish Medical Journal 24(2):151-153.

Campbell, G., M. Steinberg, and J. Bower. (1975) Ascorbic acid-induced hemolysis in G-6-PD deficiency. Annals of Internal Medicine 82(6):810.

Carr, A. and B. Frei. (1999) Does vitamin C act as a pro-oxidant under physiological conditions? The FASEB Journal 13(9):1007-1024.

Casciari, J., N. Riordan, T. Schmidt, X. Meng, J. Jackson, and H. Riordan. (2001) Cytotoxicity of ascorbate, lipoic acid, and other antioxidants in hollow fibre in vitro tumours. British Journal of Cancer 84(11):1544-1550.

Cathcart, R. (1981) Vitamin C, titrating to bowel tolerance, anascorbemia, and acute induced scurvy. Medical Hypotheses 7(11):1359-1376.

Cathcart, R. (1984) Vitamin C in the treatment of acquired immune deficiency syndrome (AIDS). Medical Hypotheses 14(4):423-433.

Cathcart, R. (1985) Vitamin C: the nontoxic, nonrate-limited, antioxidant free radical scavenger. Medical Hypotheses 18(1):61-77.

Cathcart, R. (1993) The third face of vitamin C. Journal of Orthomolecular Medicine 7(4):197-200.

Calabrese, E., G. Moore, and M. McCarthy. (1983) The effect of ascorbic acid on nitrite-induced methemoglobin formation in rats, sheep, and normal human erythrocytes. Regulatory Toxicology and Pharmacology 3(3):184-188.

Calabrese, E. (1985) Does exposure to environmental pollutants increase the need for vitamin C? Journal of Environmental Pathology, Toxicology and Oncology 5(6):81-90.

Calabrese, E., A. Stoddard, D. Leonard, and S. Dinardi. (1987) The effects of vitamin C supplementation on blood and hair levels of cadmium, lead, and mercury. Annals of the New York Academy of Sciences 498:347-353.

Carnes, C., M. Chung, T. Nakayama, H. Nakayama, R. Baliga, S. Piao, A. Kanderian, S. Pavia, R. Hamlin, P. McCarthy, J. Bauer, and D. Van Wagoner. (2001) Ascorbate attenuates atrial pacing-induced peroxynitrite formation and electrical remodeling and decreases the incidence of postoperative atrial fibrillation. Circulation Research 89(6):E32-E38.

Castrovilli, G. (1937) Contributo all terapia della intossicazione da benzolo (la vitamina C nel benzolismo sperimentale). Med del Lavoro 28:106.

Cathcart, R. (1981) Vitamin C, titrating to bowel tolerance, anascorbemia, and acute induced scurvy. Medical Hypotheses 7(11):1359-1376.

Chatterjee, I., A. Majumder, B. Nandi, and N. Subramanian. (1975) Synthesis and some major functions of vitamin C in animals. Annals of the New York Academy of Sciences 258:24-47.

Charlton, R. and T. Bothwell. (1976) Iron, ascorbic acid, and thalassemia. Birth Defects Original Article Series 12(8):63-71.

Chakraborty, D., A. Bhattacharyya, K. Majumdar, and G. Chatterjee. (1977) Effects of chronic vanadium pentoxide administration on L-ascorbic acid metabolism in rats: influence of L-ascorbic acid supplementation. International Journal for Vitamin and Nutrition Research 47(l):81-87.

Chakraborty, D., A. Bhattacharyya, K. Majumdar, K. Chatterjee, S. Chatterjee, A. Sen, and G. Chatterjee. (1978) Studies on L-ascorbic acid metabolism in rats under chronic toxicity due to organophosphorus insecticides: effects of supplementation of L-ascorbic acid in high doses. The Journal of Nutrition 108(6):973-980.

Chakraborty, D., A. Bhattacharyya, J. Chatterjee, K. Chatterjee, A. Sen, S. Chatterjee, K. Majumdar, and G. Chatterjee. (1978a) Biochemical studies on polychlorinated biphenyl toxicity in rats: manipulation by vitamin C. International Journal for Vitamin and Nutrition Research 48(1):22-31.

Challem, J. and E. Taylor. (1998) Retroviruses, ascorbate, and mutations, in the evolution of Homo sapiens. Free Radical Biology & Medicine 25(1):130-132.

Chapman, D. and C. Shaffer. (1947) Mercurial diuretics. A comparison of acute cardiac toxicity in animais and the effect of ascorbic acid on detoxification in their intravenous administration. Archives of Internal Medicine 79:449-456.

Chatterjee, A. (1967) Role of ascorbic acid in the prevention of gonadal inhibition by carbon tetrachloride. Endokrinologie 51(5-6):319-322.

Chatterjee, G., S. Banerjee, and D. Pal. (1973) Cadmium administration and L-ascorbic acid metabolism in rats: effect of L-ascorbic acid supplementation. International Journal for Vitamin and Nutrition Research 43(3):370-377.

Chatterjee, G. and D. Pal. (1975) Metabolism of L-ascorbic acid in rats under in vivo administration of mercury: effect of L-ascorbic acid supplementation. International Journal for Vitamin and Nutrition Research 45(3):284-292.

Chatterjee, G., S. Chatterjee, K. Chatterjee, A. Sahu, A. Bhattacharyya, D. Chakraborty, and P. Das. (1979) Studies on the protective effects of ascorbic acid in rubidium toxicity. Toxicology and Applied Pharmacology 51(l):47-58.

Chatterjee, K,, D. Chakraborty, K. Majumdar, A. Bhattacharyya, and G. Chatterjee. (1979) Biochemical studies on nickel toxicity in weanling rats-influence of vitamin C supplementation. International Journal for Vitamin and Nutrition Research 49(3):264-275.

Chatterjee, K., S. Banerjee, R. Tiwari, K. Mazumdar, A. Bhattacharyya, and G. Chatterjee. (1981) Studies on the protective effects of L-ascorbic acid in chronic chlordane toxicity. International Journal for Vitamin and Nutrition Research 51(3):254-265.

Chattopadhyay, S., S. Ghosh, J. Debnath, and D. Ghosh. (2001) Protection of sodium arsenite-induced ovarian toxicity by coadministration of L-ascorbate (vitamin C) in mature Wistar strain rat. Archives of Environmental Contamination and Toxicology 41(l):83-89.

Chen, C. and T. Lin. (2001) Effects of nickel chloride on human platelets: enhancement of lipid peroxidation, inhibition of aggregation and interaction with ascorbic acid. Journal of Toxicology and Environmental Health. Part A 62(6):431-438.

Chen, K., J. Suh, A. Carr, J. Morrow, J. Zeind, and B. Frei. (2000) Vitamin C suppresses oxidative lipid damage in vivo, even in the presence of iron overload. American Journal of Physiology. Endocrinology and Metabolism. 279(6):E1406-E1412.

Chang, C. and T. Lan. (1940) Vitamin C in tuberculosis. Ascorbic acid content of blood and urine of tuberculosis patients. American Review of Tuberculosis 41:494-506.

Chow, C., R. Thacker, and C. Gairola. (1979) Increased level of L-ascorbic acid in the plasma of polychlorobiphenyls-treated rats and its inhibition by dietary vitamin E. Research Communications in Chemical Pathology and Pharmacology 26(3):605-608.

Chow, C., R. Thacker, and C. Gairola. (1981) Dietary selenium and levels of L-ascorbic acid in the plasma, livers, and lungs of polychlorinated biphenyls-treated rats. International Journal for Vitamin and Nutrition Research 51(3):279-283.

Charpy, J. (1948) Ascorbic acid in very large doses alone or with vitamin D2 in tuberculosis. Bulletin de l’académie Nationale de Médecine (Paris) 132:421-423.

Cilento, P., A. Kalokerinos, I. Dettman, and G. Dettman. (1980) Venomous bites and vitamin C status. The Australasian Nurses Journal 9(6):19.

Ciocoiu, M., E. Lupusoru, V. Colev, M. Badescu, and I. Paduraru. (1998) [The involvement of vitamins C and E in changing the immune response]. Article in Romanian. Revista Medico-Chirurgicala a Societatii de Medici si Naturalisti din lasi 102(1-2):93-96.

Civil, I. and M. McDonald. (1978) Acute selenium poisoning: case report. New Zealand Medical Journal 87(612):354-356.

Cohen, G. (1977) An acetaldehyde artifact in studies of the interaction of ethanol with biogenic amine Systems: the oxidation of ethanol by ascorbic acid. Journal of Neurochemistry 29(4):761-762.

Collis, C., M. Yang, A. Diplock, T. Hallinan, and C. Rice-Evans. (1997) Effects of co-supplementation of iron with ascorbic acid on antioxidant-pro-oxidant balance in the guinea pig. Free Radical Research 27(1):113-121.

Cooke, M., M. Evans, I. Podmore, K. Herbert, N. Mistry, P. Mistry, P. Hickenbotham, A. Hussieni, H. Griffiths, and J. Lunee. (1998) Novel repair action of vitamin C upon in vivo oxidative DNA damage. FEBS Letters 439(3):363-367.

Corberand, J., F. Nguyen, B. Fraysse, and L. Enjalbert. (1982) Malignant external otitis and polymorphonuclear leukocyte migration impairment. Improvement with ascorbic acid. Archives, of Otolaryngology 108(2):122-124.

Coulehan, J., S. Eberhard, L. Kapner, F. Taylor, K. Rogers, and P. Garry. (1976) Vitamin C and acute illness in Navajo school children. The New England Journal of Medicine 295(18):973-977.

Conney, A., G. Bray, C. Evans, and J. Burns. (1961) Metabolic interactions between L-ascorbic acid and drugs. Annals of the New York Academy of Sciences 92(1):115-126.

Cooney, R., P. Ross, and G. Bartolini. (1986) N-nitrosation and N-nitration of morpholine by nitrogen dioxide: inhibition by ascorbate, glutathione and alpha-tocopherol. Cancer Letters 32(1):83-90.

Cormia, F. (1937) Experimental arsphenamine dermatitis: the influence of vitamin C in the production of arsphenamine sensitiveness. Canadian Medical Association Journal 36:392.

Creagan, E., C. Moertel, J. O’Fallon, A. Schutt, M. O’Connell, J. Rubin, and S. Frytak. (1979) Failure of high-dose vitamin C (ascorbic acid) therapy to benefit patients with advanced cancer. A controlled trial. The New England Journal of Medicine 301(13):687-690.

Cummings, M. (1981) Can some people synthesize ascorbic acid? The American Journal of Clinical Nutrition 34(2):297-298.

Curhan, G., W. Willett, E. Rimm, and M. Stampfer. (1996) A prospective study of the intake of vitamins C and B6, and the risk of kidney stones in men. Journal of Urology 155(6): 1847-1851.

Curhan, G., W. Willett, F. Speizer, and M. Stampfer (1999) Intake of vitamins B6 and C and the risk of kidney stones in women. Journal of the American Society of Nephrology 10(4):840-845.

Cumming, P., E. Wallace, J. Schorr, and R. Dodd. (1989) Exposure of patients to human immunodeficiency virus through the transfusion of blood components that test antibody-negative. The New England Journal of Medicine 321(14):941-946.

Dahl, H. and M. Degre. (1976) The effect of ascorbic acid on production of human interferon and the antiviral activity in vitro. Acta Pathologica et Microbiologica Scandinavica. Section B, Microbiology 84(5):280-284.

Davies, M., J. Austin, and D. Partridge. (1991) Vitamin C: Its Chemistry and Biochemistry. Cambridge: The Royal Society of Chemistry, Thomas Graham House.

Dainow, I. (1943) Treatment of herpès zoster with vitamin C. Dermatologia 68:197-201.

Dainow, I. (1935) Desensitizing action of L-ascorbic acid. Ann Dermat et Syph. 6:830.

Dalley, J., P. Gupta, F. Lam, and C. Hung. (1989) Interaction of L-ascorbic acid on the disposition of lead in rats. Pharmacology & Toxicology 64(4):360-364.

Dannenberg, A., A. Widerman, and P. Friedman. (1940) Ascorbic acid in the treatment of chronic lead poisoning. Report of a case of clinical failure. The Journal of the American Medical Association 114(15):1439-1440.

Davies, M., J. Austin, D. Partridge. (1991) Vitamin C: Its Chemistry and Biochemistry. Cambridge: The Royal Society of Chemistry. Thomas Graham House.

Dillard, C., K. Kunert, and A. Tappel. (1982) Effects of vitamin E, ascorbic acid and mannitol on alloxan-induced lipid peroxidation in rats. Archives of Biochemistry and Biophysics 216(1):204-212.

Dallegri, E, G. Lanzi, and E Patrone. (1980) Effects of ascorbic acid on neutrophil locomotion. International Archives of Allergy and Applied Immunology 61(l):40-45.

Dalton, W. (1962) Massive doses of vitamin C in the treatment of viral diseases. Journal of the Indiana State Medical Association August, pp.1151-1154.

Das, K., S. Das, and S. DasGupta. (2001) The influence of ascorbic acid on nickel-induced hepatic lipid peroxidation in rats. Journal of Basic and Clinical Physiology and Pharmacology 12(3):187-195.

Das, M., K. Garg, G. Singh, and S. Khanna. (1994) Attenuation of benzanthrone toxicity by ascorbic acid in guinea pigs. Fundamental and Applied Toxicology 22(3):447-456.

Dawson, E., D. Evans, W. Harris, M. Teter, and W. McGanity. (1999) The effect of ascorbic acid supplementation on the blood lead levels of smokers. Journal of the American College of Nutrition 18(2):166-170.

De, K., K. Roy, A. Saha, and C. Sengupta. (2001) Evaluation of alpha-tocopherol, probucol and ascorbic acid as suppressors of digoxin induced lipid peroxidation. Acte Poloniae Pharmaceutica 58(5):391-400.

De la Fuente, M. and V. Victor. (2001) Ascorbic acid and N-acetylcysteine improve in vitro the function of lymphocytes from mice with endotoxin-induced oxidative stress. Free Radical Research 35(l):73-84.

De la Fuente, M., M. Ferrandez, M. Burgos, A. Soler, A. Prieto, and J. Miquel. (1998) Immune function in aged women is improved by ingestion of vitamins C and E. Canadian Journal of Physiology and Pharmacology 76(4):373-380.

Desole, M., V. Anania, G. Esposito, F. Carboni, A. Senini, and E. Miele. (1987) Neurochemical and behavioural changes induced by ascorbic acid and d-amphetamine in the rat. Pharmacological Research Communications 19(6):441-450.

Destro, R. and V. Sharma. (1977) An appraisal of vitamin C in adjunct therapy of bacterial and « viral » meningitis. Clinical Pediatrics 16(10):936-939.

Dey, P. (1965) Protective action of lemon juice and ascorbic acid against lethality and convulsive property of strychnine. Die Naturwissenschaften 52:164.

Dey, P. (1966) Efficacy of vitamin C in counteracting tetanus toxicity. Die Naturwissenschaften 53(12):310.

Dey, P. (1967) Protective action of ascorbic acid & its precursors on the convulsive & lethal actions of strychnine. Indian Journal of Experimental Biology 5(2):110-112.

Dey, S., P. Nayak, and S. Roy. (2001) Chromium-induced membrane damage: protective rôle of ascorbic acid. Journal of Environmental Sciences (China) 13(3):272-275.

Dhawan, M., D. Kachru, and S. Tandon. (1988) Influence of thiamine and ascorbic acid supplementation on the antidotal efficacy of thiol chelators in experimental lead intoxication. Archives of Toxicology 62(4):301-304.

Dhir, H., K. Agarwal, A. Sharma, and G. Talukder. (1991) Modifying role of Phyllanthus emblica and ascorbic acid against nickel clastogenicity in mice. Cancer Letters 59(1):9-18.

Dirks, M., D. DaVis, E. Cheraskin, and J. Jackson. (1994) Mercury excretion and intravenous ascorbic acid. Archives of Environmental Health 49(l):49-52.

Dotsch, J., S. Demirakca, A. Cryer, J. Hanze, P. Kuhl, and W. Rascher. (1998) Reduction of NO-induced methemoglobinemia requires extremely high doses of ascorbic acid in vitro. Intensive Care Medicine 24(6):612-615.

Docampo, R., S. Moreno, and F. Cruz. (1988) Enhancement of the cytotoxicity of crystal violet against Trypanosoma cruzi in the blood by ascorbate. Molecular and Biochemical Parasitology 27(2-3):241-247.

Douglas, R., E. Chalker, and B. Treacy. (2000) Vitamin C for preventing and treating the common cold. Cochrane Database of Systematic Reviews (2):CD000980.

Dunlap, C. and F. Leslie. (1985) Effect of ascorbate on the toxicity of morphine in mice. Neuropharmacology 24(8):797-804.

Dunham, W., E. Zuckerkandl, R. Reynolds, R. Willoughby, R. Marcuson, R. Barth, and L. Pauling. (1982) Effects of intake of L-ascorbic acid on the incidence of dermal neoplasms induced in mice by ultraviolet light. Proceedings of the National Academy of Sciences of the United States of America 79(23):7532-7536.

Durak, L, H. Karabacak, S. Buyukkocak, M. Cimen, M. Kacmaz, E. Omeroglu, and H. Ozturk. (1998) Impaired antioxidant defense System in the kidney tissues from rabbits treated with cyclosporine. Protective effects of vitamins E and C. Nephron 78(2):207-211.

Dubey, S., K. Sinha, and J. Gupta. (1985) Vitamin C status, glutathione and histamine in gastric carcinoma, tuberculous enteritis and non-specific ulcerative colitis. Indian Journal of Physiology and Pharmacology 29(2):111-114.

Dubey, S., G. Palodhi, and A. Jain. (1987) Ascorbic acid, dehydroascorbic acid and glutathione in liver disease. Indian Journal of Physiology and Pharmacology 31(4):279-283.

Dvorak, M. (1989) [The effect of polychlorinated biphenyls on the vitamin A, vitamin E, and ascorbic acid status in young pigs]. Article in German. Archiv fur Experimentelle Veterinarmedizin 43(1): 51-60.

Dwenger, A., H. Pape, C. Bantel, G. Schweitzer, K. Krumm, M. Grotz, B. Lueken, M. Funck, and G. Regel. (1994) Ascorbic acid reduces the endotoxin-induced lung injury in awake sheep. European Journal of Clinical Investigation 24(4):229-235.

Dwivedi, N., M. Das, A. Joshi, G. Singh, and S. Khanna. (1993) Modulation by ascorbic acid of the cutaneous and hepatic biochemical effects induced by topically applied benzanthrone in mice. Food and Chemical Toxicology 31(7):503-508.

Eberlein-Konig, B., M. Placzek, and R. Przybilla. (1998) Protective effect against sunburn of combined systemic ascorbic acid (vitamin C) and d-alpha-tocopherol (vitamin E). Journal of the American Academy of Dermatology 38(l):45-48.

Ecker, E. and L. Pillemer. (1940) Vitamin C requirement of the guinea pig. Proceedings of the Society for Experimental Biology and Medicine 44:262.

Edwards, W. (1968) Ascorbic acid for treatment of feline rhinotracheitis. Veterinary Medicine/Small Animal Clinician 63:696-698.

Eldor, A., I. Vlodavsky, E. Riklis, and Z. Fuks. (1987) Recovery of prostacyclin capacity of irradiated endothelial cells and the protective effect of vitamin C. Prostaglandins 34(2):241-255.

Eller, C., F. Edwards, and E. Wynne. (1968) Sporicidal action of auto-oxidized ascorbic acid for Clostridium. Applied Microbiology 16(2):349-354.

Ericsson, Y. (1954) The effect of ascorbic acid oxidation on mucoids and bacteria in body secretions. Acta Pathologica et Microbiologica Scandinavica 35:573-583.

Erwin, G., R. Wright, and C. Doherty. (1940) Hypovitaminosis C and pulmonary tuberculosis. British Medical Journal 1:688-689.

Esposito, A. (1986) Ascorbate modulates antibacterial mechanisms in experimental pneumococcal pneumonia. The American Review of Respiratory Disease 133(4):643-647.

Evans, E., W. Norwood, R. Kehoe, and W. Machle. (1943) The effects of ascorbic acid in relation to lead absorption. The Journal of the American Medical Association 121(7):501-504.

Evans, R., L. Currie, and A. Campbell. (1982) The distribution of ascorbic acid between various cellular components of blood, in normal individuals, and its relation to the plasma concentration. The British Journal of Nutrition 47(3):473-482.

Everall, L, L. Hudson, and R. Kerwin. (1997) Decreased absolute levels of ascorbic acid and unaltered vasoactive intestinal polypeptide receptor binding in the frontal cortex in acquired immunodeficiency syndrome. Neuroscience Letters 224(2):119-122.

Eylar, E., I. Baez, J. Navas, and C. Mercado. (1996) Sustained levels of ascorbic acid are toxic and immunosuppressive for human T cells. Puerto Rico Health Sciences Journal 15(l):21-26.

Farah, N. (1938) Enteric fever treated with suprarenal cortex extract and vitamin C intravenously. Lancet 1:777-779.

Faulkner, J. and F. Taylor. (1937) Vitamin C and infection. Annals of Internal Medicine 10:1867-1873.

Faizallah, R., A. Morris, N. Krasner, and R. Walker. (1986) Alcohol enhances vitamin C excretion in the urine. Alcohol and Alcoholism 21(1):81-84

Farbiszewski, R., A. Witek, and E. Skrzydlewska. (2000) N-acetylcysteine or trolox derivative mitigate the toxic effects of methanol on the antioxidant system of rat brain. Toxicology 156(1):47-55.

Ferrer, E. and E. Baran. (2001) Reduction of vanadium(V) with ascorbic acid and isolation of the generated oxovanadium(IV) species. Biological Trace Element Research 83(2):111-119.

Feigen, G., B. Smith, C. Dix, C. Flynn, N. Peterson, L. Rosenberg, S. Pavlovic, and B. Leibovitz. (1982) Enhancement of antibody production and protection against systemic anaphylaxis by large doses of vitamin C. Research Communications in Chemical Pathology and Pharmacology 38(2):313-333.

Ferreira, D. (1950) Vitamin C in leprosy. Publicacoes Medicas 20:25-28.

Fang, J., S. Kinlay, J. Beltrame, H. Hikiti, M. Wainstein, D. Behrendt, J. Suh, B. Frei, G. Mudge, A. Selwyn, and P. Ganz. (2002) Effect of vitamins C and E on progression of transplant-associated arteriosclerosis: a randomized trial. Lancet 359(9312):1108-1113.

Fituri, N., N. Allawi, M. Bentley, and J. Costello. (1983) Urinary and plasma oxalate during ingestion of pure ascorbic acid: a re-evaluation. Europeen Urology 9(5):312-315.

Findlay, G. (1923) The relation of vitamin C to bacterial infection. Journal of Pathology and Bacteriology 26(1):1-19.

Fighera, M., C, Queiroz, M. Stracke, M. Brauer, L. Gonzalez-Rodriguez, R. Frussa-Filho, M. Wajner, and C. de Mello. (1999) Ascorbic acid and alpha-tocopherol attenuate methylmalonic acid-induced convulsions. Neuroreport 10(10):2039-2043.

Flora, S. and S. Tandon. (1986) Preventive and therapeutic effects of thiamine, ascorbic acid and their combination in lead intoxication. Acta Pharmacologica et Toxicologica (Copenh) 58(5):374-378.

Floch, H. and P. Sureau. (1952) Vitamin C therapy in leprosy. Bulletin de la Société de Pathologie Exotique et de Ses Filiales (Paris) 45:443-446.

Forbes, J. and G. Duncan. (1954) Effect of alcohol intoxication and ACTH on liver ascorbic acid in the guinea pig. Endocrinology 55: 822-827.

Foster, D., E. Obineche, and N. Traub. (1974) The effect of pyridoxine, folic acid and ascorbic acid therapy on the incidence of sideroblastic anaemia in Zambians with chloramphenicol treated typhoid. A preliminary report. East African Medical Journal 51(1): 20-25.

Forssman, S. and K. Frykholm. (1947) Benzene poisoning. II. Examination of workers exposed to benzene with reference to the presence of ester sulfate, muconic acid, urochrome A and polyphenols in the urine together with vitamin C deficiency. Prophylactic measures. Acta Medica Scandinavica 128(3):256-280.

Fox, M. and B. Fry. (1970) Cadmium toxicity decreased by dietary ascorbic acid supplements. Science 169(949):989-991.

Fox, M. (1975) Protective effects of ascorbic acid against toxicity of heavy metals. Annals of the New York Academy of Sciences 258:144-150.

Fraga, C., P. Motchnik, M. Shigenaga, H. Helbock, R. Jacob, and B. Ames. (1991) Ascorbic acid protects against endogenous oxidative DNA damage in human sperm. Proceedings of the National Academy of Sciences of the United States of America 88(24):11003-11006.

Fraser, R., S. Pavlovic, C. Kurahara, A. Murata, N. Peterson, K. Taylor, and G. Feigen. (1980) The effect of variations in vitamin C intake on the cellular immune response of guinea pigs. The American Journal of Clinical Nutrition 33(4):839-847.

Frei, B., L. England, and B. Ames. (1989) Ascorbate is an outstanding antioxidant in human blood plasma. Proceedings of the National Academy of Sciences ofthe United States of America 86(16):6377-6381.

Frei, B., R. Stocker, L. England, and B. Ames. (1990) Ascorbate: the most effective antioxidant in human blood plasma. Advances in Experimental Medicine and Biology 264:155-163.

Friend, t). and H. Marquis. (1936) Arsphenamine sensitivity and vitamin C. American Journal of Syphilis, Gonorrhea and Venereal Diseuses 22:239-242.

Fuller, C., S. Grundy, E. Norkus, and I. Jialal. (1996) Effect of ascorbate supplementation on low density lipoprotein oxidation in smokers. Atherosclerosis 119(2):139-150.

Fujimoto, Y., E. Nakatani, M. Horinouchi, K. Okamoto, S. Sakuma, and T. Fujita. (1989) Inhibition of paraquat accumulation in rabbit kidney cortex slices by ascorbic acid. Research Communications in Clinical Pathology and Pharmacology 65(2):245-248.

Fujita, K., K. Shinpo, K. Yamada, T. Sato, N. Niimi, M. Shamoto, T. Nagatsu, T. Takeuchi, and H. Umezawa. (1982) Reduction of adriamycin toxicity by ascorbate in mice and guinea pigs. Cancer Research 420:309-316.

Fujiwara, M. and K. Kuriyama. (1977) Effect of PCB (polychlorobiphenyls) on L-ascorbic acid, pyridoxal phosphate and riboflavin contents in various organs and on hepatic metabolism of L-ascorbic acid in the rat. Japanese Journal of Pharmacology 27(5):621-627.

Fuller, R., E. Henson, E. Shannon, A. Collins, and J. Brunson. (1971) Vitamin C deficiency and susceptibility to endotoxin shock in guinea pigs. Archives of Pathology 92(4):239-243.

Fulton, B. and E. Jeffery. (1990) Absorption and retention of aluminum from drinking water. 1. Effect of citric and ascorbic acids on aluminum tissue levels in rabbits. Fundamental and Applied Toxicology 14(4):788-796.

Ganguly, R., M. Durieux, and R. Waldman. (1976) Macrophage function in vitamin C-deficient guinea pigs. The American Journal of Clinical Nutrition 29(7):762-765.

Gatti, C. and R. Gaona. (1939) Ascorbic acid in the treatment of leprosy. Archiv Schiffe-und Tropenhygiene 43:32-33.

Gage, J. (1975) Mechanisms for the biodegradation of organic mercury compounds: the actions of ascorbate and of soluble proteins. Toxicolagy and Applied Pharmacology 32(2):225-238.

Gao, E, J. Yi, G. Shi, H. Li, X. Shi, Z. Wang, and X. Tang. (2002) [Ascorbic acid enhances the apoptosis of U937 cells induced by arsenic trioxide in combination with DMNQ and its mechanism]. Article in Chinese. Zhonghua Xueyexue Zazhi 23(1):9-11.

Gao, E, C. Yao, E. Gao, Q. Mo, W. Yan, R. McLaughlin, B. Lopez, T. Christopher, and X. Ma. (2002a) Enhancement of glutathione cardioprotection by ascorbic acid in myocardial reperfusion injury. The Journal of Pharmacology and Experimental Therapeutics 301(2): 543-550.

Garcia, R. and A. Municio. (1990) Effect of Escherichia coli endotoxin on ascorbic acid transport in isolated adrenocortical cells. Proceedings of the Society for Experimental Biology and Mediane 193(4):280-284.

Garcia-Roche, M., A. Castillo, T. Gonzalez, M. Grillo, J. Rios, and N. Rodriguez. (1987) Effect of ascorbic acid on the hepatoxicity due to the daily intake of nitrate, nitrite and dimethylamine. Die Nahrung 31(2):99-104.

Garg, K., S. Khanna, M. Das, and G. Singh. (1992) Effect of extraneous supplementation of ascorbic acid on the bio-disposition of benzanthrone in guinea pigs. Food and Chemical Toxicology 30(11): 967-971.

Gaker, L. and N. Butcher. (1986) Dissolution of staghorn calculus associated with amiloride-hydrochlorothiazide, sulfamethoxazole and trimethoprim, and ascorbic acid. The Journal of Urology 135(5):933-934.

Geetanjali, D., P. Rita, and P. Reddy. (1993) Effect of ascorbic acid in the detoxification of the insecticide dimethoate in the bone marrow erythrocytes of mice. Food and Chemical Toxicology 31(6):435-437.

Geetha, A., J. Catherine, and C. Shyamala Devi. (1989) Effect of alpha-tocopherol on the microsomal lipid peroxidation induced by doxorubicin: influence of ascorbic acid. Indian Journal of Physiology and Pharmacology 33(l):53-58.

Gerster, H. (1997) No contribution of ascorbic acid to renal calcium oxalate stones. Annals of Nutrition & Metabolism 41(5):269-282.

Gerster, H. (1999) High-dose vitamin C: a risk for persons with high iron stores? International Journal for Vitamin and Nutrition Research 69(2):67-82.

Geber, W., S. Lefkowitz, and C. Hung. (1975) Effect of ascorbic acid, sodium salicylate, and caffeine on the serum interferon level in response to viral infection. Pharmacology 13(3):228-233.

Getz, H. and T. Koerner. (1941) Vitamin A and ascorbic acid in pulmonary tuberculosis. Determination in plasma by the photoelectric colorimeter. The American Journal of the Medical Sciences 202:831-847.

Getz, H., E. Long, and H. Henderson. (1951) A study of the relation of nutrition to the development of tuberculosis. Influence of ascorbic acid and vitamin A. American Review of Tuberculosis 64:381-393.

Ghaskadbi, S., S. Rajmachikar, C. Agate, A. Kapadi, and V. Vaidya. (1992) Modulation of cyclophosphamide mutagenicity by vitamin C in the in vivo rodent micronucleus assay. Teratogenesis, Carcinogenesis, and Mutagenesis 12(1):11-17.

Ghosh, S., D. Ghosh, S. Chattopadhyay, and J. Debnath. (1999) Effect of ascorbic acid supplementation on liver and kidney toxicity in cyclophosphamide-treated female albino rats. The Journal of Toxicological Sciences 24(3):141-144.

Giannini, A., R. Loiselle, L. DiMarzio, and M. Giannini. (1987) Augmentation of haloperidol by ascorbic acid in phencyclidine intoxication. The American Journal of Psychiatry 144(9):1207-1209.

Ginter, E. (1976) Ascorbic acid synthesis in certain guinea pigs. International Journal for Vitamin and Nutrition Research 46(2):173-179.

Ginter, E., D. Chorvatovicova, and A. Kosinova. (1989) Vitamin C lowers mutagenic and toxic effect of hexavalent chromium in guinea pigs. International Journal for Vitamin and Nutrition Research 59(2):161-166.

Ginter, E., Z. Zloch, and R. Ondreicka. (1998) Influence of vitamin C status on ethanol metabolism in guinea-pigs. Physiological Research 47(2):137-141.

Ginter, E. and Z. Zloch. (1999) Influence of vitamin C status on the metabolic rate of a single dose of ethanol-1-(14)C in guinea pigs. Physiological Research 48(5):369-373.

Giri, A., D. Khynriam, and S. Prasad. (1998) Vitamin C mediated protection on cisplatin induced mutagenicity in mice. Mutation Research 421(2):139-148.

Girotti, A., J. Thomas, and J. Jordan. (1985) Lipid photooxidation in erythrocyte ghosts: sensitization of the membranes toward ascorbate-and superoxide-induced peroxidation and lysis. Archives of Biochemistry and Biophysics 236(1):238-251.

Girotti, A., J. Thomas, and J. Jordan. (1985a) Prooxidant and antioxidant effects of ascorbate on photosensitized peroxidation of lipids in erythrocyte membranes. Photochemistry and Photobiology 41(3):267-276.

Giulivi, C. and E. Cadenas. (1993) The reaction of ascorbic acid with different heme iron redox states of myoglobin. Antioxidant and prooxidant aspects. FEBS Letters 332(3):287-290.

Glazebrook, A. and S. Thomson. (1942) The administration of vitamin C in a large institution and its effect on general health and resistance to infection. Journal of Hygiene 42(1):1-19.

Glascott, P., E. Gilfor, A. Serroni, and J. Farber. (1996) Independent antioxidant action of vitamins E and C in cultured rat hepatocytes intoxicated with allyl alcohol. Biochemical Pharmacology 52(8):1245-1252.

Glick, D. and S. Hosoda. (1965) Histochemistry. LXXViii. Ascorbic acid in normal mast cells and macrophages and neoplastic mast cells. Proceedings of the Society for Experimental Biology and Medicine 119:52-56.

Gnarpe, H., M. Michaelsson, and S. Dreborg. (1968) The in vitro effect of ascorbic acid on the bacterial growth in urine. Acta Pathologica et Microbiologica Scandinavica 74(1):41-50.

Godeau, B. and P. Bierling. (1990) Treatment of chronic autoimmune thrombocytopenic purpura with ascorbate. British Journal of Haemotology 75(2):289-290.

Goetzl, E., S. Wasserman, I. Gigli, and K. Austen. (1974) Enhancement of random migration and chemotactic response of human leukocytes by ascorbic acid. The Journal of Clinical Investigation 53(3):813-818.

Gontea, L, S. Dumitrache, A. Rujinski, and M. Draghicescu. (1969) Influence of chronic benzene intoxication on vitamin C in the guinea pig and rat. Igiena 18:1-11.

Gontzea, J. et al. (1963) The vitamin C requirements of lead workers. Internationale Zeitschrift fur Augenwardte Phisiologie Einschliesslich Arbeits Physiologie (Berlin) 20:20-33.

Goyer, R. and M. Cherian. (1979) Ascorbic acid and EDTAtreatment of lead toxicity in rats, Life Sciences 24(5):433-438.

Goldschmidt, M. (1991) Reduced bactericidal activity in neutrophils from scorbutic animals and the effect of ascorbic acid on these target bacteria in vivo and in vitro. The American Journal of Clinical Nutrition 54(6 Suppl):1214S-1220S.

Gorton, H. and K. Jarvis. (1999) The effectiveness of vitamin C in preventing and relieving the symptoms of virus-induced respiratory infections. Journal of Manipulative and Physiological Therapeutics 22(8):530-533.

Green, M., J. Lowe, A. Waugh, K. Aldridge, J. Cole, and C. Arlett. (1994) Effect of diet and vitamin C on DNA strand breakage in freshly-isolated human white blood cells. Mutation Research 316(2):91-102.

Grabarczyk, M., U. Podstawka, and J. Kopec-Szlezak. (1991) [Protection of human peripheral blood leukocytes with vitamin E and C from toxic effects of fenarimol in vitro]. Article in Polish. Acta Haematologica Polonica 22(1):136-144.

Grad, J., N. Bahlis, I. Reis, M. Oshiro, W. Dalton, and L. Boise. (2001) Ascorbic acid enhances arsenic trioxide-induced cytotoxicity in multiple myeloma cells. Blood 98(3):805-813.

Greggi Antunes, L, J. Darin, and M. Blanchi. (2000) Protective effects of vitamin C against cisplatin-induced nephrotoxicity and lipid peroxidation in adult rats: a dose-dependent study. Pharmacological Research 41(4):405-411.

Grosse, Y., L. Chekir-Ghedira, A. Hue, S. Obrecht-Pflumio, G. Dirheimer, H. Bâcha, and A. Pfohl-Leszkowicz. (1997) Retinol, ascorbic acid and alpha-tocopherol prevent DNA adduct formation in mice treated with the mycotoxins ochratoxin A and zearalenone. Cancer Letters 114(l-2):225-229.

Grollman, A. and A. Lehninger. (1957) Enzymic synthesis of L-ascorbic acid in different animal species. Archives of Biochemistry and Biophysics 69:458-467.

Greenwald, C. and E. Harde. (1935) Vitamin C and diphtheria toxin. Proceedings of the Society for Experimental Biology and Medicine 32: 1157-1160.

Greer, E. (1955) Vitamin C in acute poliomyelitis. Medical Times 83(11): 1160-1161.

Greene, M., M. Steiner, and B. Kramer. (1936) The role of chronic vitamin-C deficiency in the pathogenesis of tuberculosis in the guinea pig. American Review of Tuberculosis 33:585-624.

Gultekin, E, N. Delibas, S. Yasar, and I. Kilinc. (2001) In vivo changes in antioxidant systems and protective role of melatonin and a combination of vitamin C and vitamin E on oxidative damage in erythrocytes induced by chlorpyrifos-ethyl in rats. Archives of Toxicology 75(2):88-96.

Gupta, P. and A. Kar. (1998) Role of ascorbic acid in cadmium-induced thyroid dysfunction and lipid peroxidation. Journal of Applied Toxicology 18(5):317-320.

Gunzel, W. and G. Kroehnert. (1937) Experiences in the treatment of pneumonia with vitamin C. Fortschrifte der Therapie 13:460-463.

Gupta, G. and B. Guha. (1941) The effect of vitamin C and certain other substances on the growth of microorganisms. Annals of Biochemistry and Experimental Medicine l(l):14-26.

Hamdy, A., W. Pounden, A. Trapp, D. Redman, and D. Bell. (1967) Effect of vitamin C on lamb pneumonia and mortality. The Cornell Veterinarian 57(1):12-20.

Harde, E. and M. Philippe. (1934) Observations sur le pouvoir antigène du mélange toxine diphtérique et vitamine C. Compt rend Acad d sc 199:738-739.

Hajarizadeh, H., L. Lebredo, R. Barrie, and E. Woltering. (1994) Protective effect of doxorubicin in vitamin C or dimethyl sulfoxide against skin ulceration in the pig. Annals of Surgical Oncology 1(5): 411-414.

Halimi, J. and A. Mimran. (2000) Systemic and renal effect of nicotine in non-smokers: influence of vitamin C. Journal of Hypertension 18(11):1665-1669.

Han-Wen, H. et al. (1959) Treatment of lead poisoning. II. Experiments on the effect of vitamin C and rutin. Chinese Journal Internai Medicine 7:19-20.

Hatch, G., R. Slade, M. Selgrade, and A. Stead. (1986) Nitrogen dioxide exposure and lung antioxidants in ascorbic acid-deficient guinea pigs. Toxicology and Applied Pharmacology 82(2):351-359.

Haskell, B. and C. Johnston. (1991) Complement component C1q activity and ascorbic acid nutriture in guinea pigs. The American Journal of Clinical Nutrition 54(6 Suppl):1228S-1230S.

Hasselbach, F. (1935) Therapy of tuberculosis pulmonary hemorrhages with vitamin C. Fortschrift der Therapie 7:407-411.

Hastings, R., V. Richard, Jr., S. Christy, and M. Morales. (1976) Activity of ascorbic acid in inhibiting the multiplication of M. leprae in the mouse foot pad. International Journal of Leprosy and Other Mycobacterial Diseases 44(4):427-430.

Harakeh, S., R. Jariwalla, and L. Pauling. (1990) Suppression of human immunodeficiency virus replication by ascorbate in chronically and acutely infected cells. Proceedings of the National Academy of Sciences of the United States of America 87(18):7245-7249.

Harakeh, S. and R. Jariwalla. (1991) Comparative study of the anti-HIV activities of ascorbate and thiol-containing reducing agents in chronically HIV-infected cells. The American Journal of Clinical Nutrition 54(6 Suppl):1231S-1235S.

Harakeh, S. and R. Jariwalla. (1997) NF-kappa B-independent suppression of HIV expression by ascorbic acid. AIDS Research and Human Retroviruses 13(3):235-239.

Halliwell, B. (1996) Vitamin C: antioxidant or pro-oxidant in vivo?Free Radical Research 25(5):439-454.

Hanck, A. (1982) Tolerance and effects of high doses of ascorbic acid. Dosis facit venenum. International Journal for Vitamin and Nutrition Research. Supplement 23:221-238

Harats, D., M. Ben-Naim, Y. Dabach, G. Hollander, E. Havivi, O. Stein, and Y. Stein. (1990) Effect of vitamin C and E supplementation on susceptibility of plasma lipoproteins to peroxidation induced by acute smoking. Atherosderosis 85(1): 47-54.

Harats, D., S. Chevion, M. Nahir, Y. Norman, O. Sagee, and E. Berry. (1998) Citrus fruit supplementation reduces lipoprotein oxidation in young men ingesting a diet high in saturated fat: presumptive evidence for an interaction between vitamins C and E in vivo. The American Journal of Clinical Nutrition 67(2): 240-245.

Hatch, M., S. Mulgrew, E. Bourke, B. Keogh, and J. Costello. (1980) Effect of megadoses of ascorbic acid on serum and urinary oxalate. European Urology 6(3):166-169.

Helen, A. and P. Vijayammal. (1997) Vitamin C supplementation on hepatic oxidative stress induced by cigarette smoke. Journal of Applied Toxicology 17(5):289-295.

Hemila, H., J. Kaprio, P. Pietinen, D. Albanes, and O. Heinonen. (1999) Vitamin C and other compounds in vitamin C rich food in relation to risk of tuberculosis in male smokers. American Journal of Epidemiology 150(6):632-641.

Heuser, G. and A. Vojdani. (1997) Enhancement of natural killer cell activity and T and B cell function by buffered vitamin C in patients exposed to toxic chemicals: the role of protein kinase-C. Immunopharmacalogy and Immunotoxicology 19(3):291-312.

He, Y. and D. Hader. (2002) UV-B-induced formation of reactive oxygen species and oxidative damage of the cyanobacterium Anabaena sp.: protective effects of ascorbic acid and N-acetyl-L-cysteine. Journal of Photochemistry and Photobiology. B, Biology 66(2):115-124.

Heise, F. and G. Martin. (1936) Ascorbic acid metabolism in tuberculosis. Proceedings of the Society for Experimental Biology and Medicine 34:642-644.

Heise, F. and G. Martin. (1936a) Supervitaminosis C in tuberculosis. Proceedings of the Society for Experimental Biology and Medicine 35:337-338.

Heise, F., G. Martin, and S. Schwartz. (1937) The influence of the administration of vitamin C on blood sedimentation and sensitivity to tuberculin. British Journal of Tuberculosis 31:23-31.

Hemila, H. (1994) Does vitamin C alleviate the symptoms of the common cold?-a review of current evidence. Scandinavian Journal of Infections Disease 26(l):l-6.

Hemila, H. (1996) Vitamin C, the placebo effect, and the common cold: a case study of how preconceptions influence the analysis of results. Journal of Clinical Epidemiology 49(10):1079-1084.

Hemila, H. (1997) Vitamin C intake and susceptibility to pneumonia. The Pediatric Infectious Disease Journal 16(9):836-837.

Hemila, H. and R. Douglas. (1999) Vitamin C and acute respiratory infections. The International Journal of Tuberculosis and Lung Disease 3(9):756-761.

Hill, C. (1979) Studies on the ameliorating effect of ascorbic acid on mineral toxicities in the chick. The Journal of Nutrition 109(1):84-90.

Hirneth, H. and H. Classen. (1984) Inhibition of nitrate-induced increase of plasma nitrite and methemoglobinemia in rats by simultaneous feeding of ascorbic acid or tocopherol. Arzneimittelforschung 34(9):988-991.

Hokama, S., C. Toma, M. Jahana, M. Iwanaga, M. Morozumi, T. Hatano, and Y. Ogawa. (2000) Ascorbate conversion to oxalate in alkaline milieu and Proteus mirabilis culture. Molecular Urology 4(4):321-328.

Hoda, Q. and S. Sinha. (1991) Minimization of cytogenetic toxicity of malathion by vitamin C. Journal of Nutritional Science and Vitaminology 37(4):329-339.

Hoda, Q. and S. Sinha. (1993) Vitamin C-mediated minimisation of Rogor-induced genotoxicity. Mutation Research 299(l):29-36.

Hoda, Q., M. Azfer, and S. Sinha. (1993) Modificatory effect of vitamin C and vitamin B-complex on meiotic inhibition induced by organophosphorus pesticide in mice Mus musculus. International Journal for Vitamin and Nutrition Research 63(1):48-51.

Holden, M. and R. Resnick. (1936) The in vitro action of synthetic crystalline vitamin C (ascorbic acid) on herpes virus. Journal of Immunology 31:455-462.

Holden, M. and E. Molloy. (1937) Further experiments on the inactivation of herpes virus by vitamin C (L-ascorbic acid). Journal of Immunology 33:251-257.

Honjo, S. and K. Imaizumi. (1967) Ascorbic acid content of adrenal and liver in cynomolgus monkeys suffering from bacillary dysentery. Japanese Journal of Medical Science & Biology 20(1):97-102.

Honjo, S., M. Takasaka, T. Fujiwara, K. Imaizumi, and H. Ogawa. (1969) Shigellosis in cynomolgus monkeys (Macaca irus) VII. Experimental production of dysentery with a relatively small dose of Shigella flexneri 2a in ascorbic acid deficient monkeys. Japanese Journal of Medical Science & Biology 22(3):149-162.

Hovi, T., A. Hirvimies, M. Stenvik, E. Vuola, and R. Pippuri. (1995) Topical treatment of recurrent mucocutaneous herpes with ascorbic acid-containing solution. Antiviral Research 27(3):263-270.

Hoehler, D. and R. Marquardt. (1996) Influence of vitamins E and C on th toxic effects of ochratoxin A and T-2 toxin in chicks. Poultry Science 75(12):1508-1515.

Holmes, H., K. Campbell, and E. Amberg. (1939) Effect of vitamin C on lead poisoning. Journal of Laboratory and Clinical Medicine 24:1119-1127.

Hong, S., D. Anestis, J. Bail, M. Valentovic, P. Brown, and G. Rankin. (1997) 4-Amino 2,6-dichlorophenol nephrotoxicity in the Fisher 344 rat: protection by ascorbic acid, AT-125, and aminooxyacetic acid. Toxicology and Applied Pharmacology 147(1):115-125.

Hong, S., K. Hwang, E. Lee, S. Eun, S. Cho, C. Han, Y. Park, and S. Chang. (2002) Effect of vitamin C on plasma total antioxidant status in patients with paraquat intoxication. Toxicology Letters 126(l):51-59.

Horio, F. and A. Yoshida. (1982) Effects of some xenobiotics on ascorbic acid metabolism in rats. The Journal of Nutrition 112(3):416-425.

Horio, F., M. Kimura, and A. Yoshida. (1983) Effects of several xenobiotics on the activities of enzymes affecting ascorbic acid synthesis in rats. Journal of Nutritional Science and Vitaminology 29(3):233-247.

Horio, F., K. Ozaki, M. Kohmura, A. Yoshida, S. Makino, and Y. Hayashi. (1986) Ascorbic acid requirement for the induction of microsomal drug-metabolizing enzymes in a rat mutant unable to synthesize ascorbic acid. The Journal of Nutrition 116(11):2278-2289.

Houston, D. and M. Johnson. (2000) Does vitamin C intake protect against lead toxicity? Nutrition Reviews 58(3 Pt 1):73-75.

Hsu, P., M. Liu, C. Hsu, L. Chen, and Y. Guo. (1998) Effects of vitamin E and/or C on reactive oxygen species-related lead toxicity in the rat sperm. Toxicology 128(3):169-179.

Hudecova, A. and E. Ginter. (1992) The influence of ascorbic acid on lipid peroxidation in guinea pigs intoxicated with cadmium. Food and Chemical Toxicology 30(12):1011-1013.

Hughes, C, S. Dutton, and A. Truswell. (1981) High intakes of ascorbic acid and urinary oxalate. Journal of Human Nutrition 35(4):274-280.

Hultqvist, M., J. Hegbrant, C. Nilsson-Thorell, T. Lindholm, P. Nilsson, T. Linden, and U. Hultqvist-Bengtsson. (1997) Plasma concentrations of vitamin C, vitamin E and/or malondialdehyde as markers of oxygen free radical production during hemodialysis. Clinical Nephrology 47(l):37-46.

Hunt, C., N. Chakravorty, G. Annan, N. Habibzadeh, and C. Schorah. (1994) The clinical effects of vitamin C supplementation in elderly hospitalized patients with acute respiratory infections. International Journal for Vitamin and Nutrition Research 64(3):212-219.

Jacques-Silva, M., C. Nogueira, L. Broch, E. Flores, and J. Rocha. (2001) Diphenyl diselenide and ascorbic acid changes deposition of selenium and ascorbic acid in liver and brain of mice. Pharmacology & Toxicology 88(3):119-125.

Jahan, K., K. Ahmad, and M. Ali. (1984) Effect of ascorbic acid in the treatment of tetanus. Bangladesh Medical Research Council Bulletin 10(l):24-28.

Jacob, H. and J. Jandl. (1966) A simple visual screening test for glucose-6-phosphate dehydrogenase deficiency employing ascorbate and cyanide. The New England Journal of Medicine 274(21):1162-1167.

Jahan, K., K. Ahmad, and M. Ali. (1984) Effect of ascorbic acid in the treatment of tetanus. Bangladesh Medical Research Council Bulletin 10(l):24-28.

Jefferies, C. (1965) Effect of endotoxin on liver ascorbic acid of mice. Journal of Bacteriology 89: 922-923.

Jeng, K., C. Yang, W. Siu, Y. Tsai, W. Liao, and J. Kuo. (1996) Supplementation with vitamins C and E enhances cytokine production by peripheral blood mononuclear cells in healthy adults. The American Journal of Clinical Nutrition 64(6):960-965.

Jetter, T. and T. Bumbalo. (1938) The urinary output of vitamin C in active tuberculosis in children. American Journal of Medical Science 195:362-366.

Joffe, M., N. Sukha, and A. Rabson. (1983) Lymphocyte subsets in measles. Depressed helper / inducer subpopulation reversed by in vitro treatment with levamisole and ascorbic acid. The Journal of Clinical Investigation 72(3):971-980.

Johnston, C., W. Kolb, and B. Haskell. (1987) The effect of vitamin C nutriture on complement component C1q concentrations in guinea pig plasma. The Journal of Nutrition 117(4):764-768.

Johnston, C., L. Martin, and X. Cai. (1992) Antihistamine effect of supplemental ascorbic acid and neutrophil chemotaxis. Journal of the American College of Nutrition 11(2):172-176.

Jonker, D., V. Lee, R. Hargreaves, and B. Lake. (1988) Comparison of the effects of ascorbyl palmitate and L-ascorbic acid on paracetamol-induced hepatotoxicity in the mouse. Toxicology 52(3):287-295.

Josewich, A. (1939) Value of vitamin C therapy in lung tuberculosis. Medical Bulletin of the Veterans Administration 16:8-11.

Jungeblut, C. (1935) Inactivation of poliomyelitis virus in vitro by crystalline vitamin C (ascorbic acid). Journal of Experimental Medicine 62:517-521.

Jungeblut, C. (1937) Vitamin C therapy and prophylaxis in experimental poliomyelitis. Journal of Experimental Medicine 65: 127-146.

Jungeblut, C. (1937a) Further observations on vitamin C therapy in experimental poliomyelitis. Journal of Experimental Medicine 66: 459-477.

Jungeblut, C. (1937b) Inactivation of tetanus toxin by crystalline vitamin C (L-ascorbic acid). Journal of lmmunology 33:203-214.

Jungeblut, C. (1939) A further contribution to vitamin C therapy in experimental poliomyelitis. Journal of Experimental Medicine 70: 315-332.

Jungeblut, C. and R. Zwemer. (1935) Inactivation of diphtheria toxin in vivo and in vitro by crystalline vitamin C (ascorbic acid). Proceedings of the Society for Experimental Biology and Medicine 32: 1229-1234.

Jurima-Romet, M., F. Abbott, W. Tang, H. Huang, and L. Whitehouse. (1996) Cytotoxicity of unsaturated metabolites of valproic acid and protection by vitamins C and E in glutathione-depleted rat

hepatocytes. Toxicology 112(l):69-85.

Kaiser, A. and B. Slavin. (1938) The incidence of hemolytic streptococci in the tonsils of children as related to the vitamin C content of tonsils and blood. Journal of Pediatrics 13:322-333.

Kameta, T. (1959) Studies on the effects of ACTH, cortisone and adrenaline on ascorbic acid in rabbits’ organs. [Japanese] Japanese Journal of Urology 50:1214-1224.

Kaplan, A. and M. Zonnis. (1940) Vitamin C in pulmonary tuberculosis. American Review of Tuberculosis 42:667-673.

Karlowski, T., T. Chalmers, L. Frenkel, A. Kapakian, T. Lewis, and J. Lynch. (1975) Ascorbic acid for the common cold. A prophylactic and therapeutic trial. The Journal of the American Medical Association 231(10):1038-1042.

Karpinska, T., Z. Kawecki, and M. Kandefer-Szerszen. (1982) The influence of ultraviolet irradiation, L-ascorbic acid and calcium chloride on the induction of interferon in human embryo fibroblasts. Archivum Immunologiae et Therapiae Experimentalis 30(1-2)33-37.

Kataoka, A., H. Imai, S. Inayoshi, and T. Tsuda. (1993) Intermittent high-dose vitamin C therapy in patients with HTLV-1 associated myelopathy. Journal of Neurology, Neurosurgery, and Psychiatry 56(11):1213-1216.

Kataoka, A., H. Imai, S. Inayoshi, and T. Tsuda. (1993a) [Intermittent high-dose vitamin C therapy in patients with HTLV-1-associated myelopathy]. Article in Japanese. Rinsho Shinkeigaku. Clinical Neurology 33(3):282-288.

Kadrabova, J., A. Madaric, and E. Ginter. (1992) The effect of ascorbic acid on cadmium accumulation in guinea pig tissues. Experientia 48(10):989-991.

Kao, H., S. Jai, and Y. Young. (1965) [A study of the therapeutic effect of large dosage of injection ascorbici acidi on the depression of the central nervous system as in acute poisoning due to barbiturates]. Article in Chinese. Acta Pharmaceutica Sinica 12(ll):764-765.

Kawai-Kobayashi, K. and A. Yoshida. (1986) Effect of dietary ascorbic acid and vitamin E on metabolic changes in rats and guinea pigs exposed to PCB. The Journal of Nutrition 116(1):98-106.

Kawai-Kobayashi, K. and A. Yoshida. (1988) Effect of polychlorinated biphenyls on lipids and ascorbic acid metabolism in streptozotocin-induced diabetic rats. Journal of Nutritional Science and Vitaminology 34(3):281-291.

Kalokerinos, A., I. Dettman, and G. Dettman. (1981) Vitamin C. The dangers of calcium and safety of sodium ascorbate. The Australasian Nurses Journal 10(3):22.

Kalokerinos, A., I. Dettman, and G. Dettman. (1982) Ascorbate-the proof of the pudding! A selection of case histories responding to ascorbate. The Australasian Nurses Journal 11(2):18-21.

Kang, S., Y. Jang, and H. Park. (1998) In vivo dual effects of vitamin C on paraquat-induced lung damage: dependance on released metals from the damaged tissue. Free Radical Research 28(1):93-107.

Kennes, B., I. Dumont, D. Brohee, C. Hubert, and P. Neve. (1983) Effect of vitamin C supplements on cell-mediated immunity in old people. Gerontology 29(5):305-310.

Kennedy, M., K. Bruninga, E. Mutlu, J. Losurdo, S. Choudhary, and A. Keshavarzian. (2001) Successful and sustained treatment of chronic radiation proctitis with antioxidant vitamins E and C. The American Journal of Gastroenterology 96(4):1080-1084.

Khaw, K., S. Bingham, A. Welch, R. Luben, N. Wareham, S. Oakes, and N. Day. (2001) Relation between ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition. Lancet 357(9257) :657-663.

Khan, P. and S. Sinha. (1994) Impact of higher doses of vitamin C in modulating pesticide genotoxicity. Teratogenesis, Carcinogenesis, and Mutagenesis 14(4):175-181.

Khan, P. and S. Sinha. (1996) Ameliorating effect of vitamin C on murine sperm toxicity induced by three pesticides (endosulfan, phosphamidon and mancozeb). Mutagenesis 11(1):33-36.

Khaw, K., S. Bingham, A. Welch, R. Luben, N. Wareham, S. Oakes, and N. Day. (2001) Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition. Lancet 357(9257):657-663.

Kimura, H., Y. Yamada, Y. Morita, H. Ikeda, and T. Matsuo. (1992) Dietary ascorbic acid depresses plasma and low density lipoprotein lipid peroxidation in genetically scorbutic rats. The Journal of Nutrition 122(9):1904-1909.

Kimbarowski, J. and N. Mokrow. (1967) [Colored precipitation reaction of the urine according to Kimbarowski (FARK) as an index of the effect of ascorbic acid during treatment of viral influenza]. Article in German. Das Deutsche Gesundheitswesen 22(51):2413-2418.

Kirchmair, H. (1957) [Treatment of epidemic hepatitis in children with high doses of ascorbic acid]. Article in German. Medizinische Monatschrift 11:353-357.

Kirchmair, H. (1957a) [Ascorbic acid treatment of epidemic hepatitis in children]. Article in German. Das Deutsche Gesundheitswesen 12:773-774.

Kirchmair, H. (1957b) [Epidemic hepatitis in children and its treatment with high doses of ascorbic acid]. Article in German. Das Deutsche Gesundheitswesen 12:1525-1536.

King, C. (1936) Vitamin C, ascorbic acid. Physiological Reviews 16:238-262.

Kirsch, M. and H. de Groot. (2000) Ascorbate is a potent antioxidant against peroxynitrite-induced oxidation reactions. Evidence that ascorbate acts by re-reducing substrate radicals produced by peroxynitrite. The Journal of Biological Chemistry 275(22):16702-16708.

Klenner, F. (1954) Recent discoveries in the treatment of lockjaw with vitamin C and Tolserol. Tri-State Medical Journal July; pp. 7-11.

Klenner, F. (1974) Significance of high daily intake of ascorbic acid in preventive medicine. Journal of the International Academy of Preventive Medicine 1(1):45-69.

Klenner, F. (February 1948) Virus pneumonia and its treatment with vitamin C. Southern Medicine & Surgery 110(2):36-38,46.

Klenner, F. (July 1949) The treatment of poliomyelitis and other virus diseases with vitamin C. Southern Medicine & Surgery 111(7):209-214.

Klenner, F. (April 1951) Massive doses of vitamin C and the virus diseases. Southern Medicine & Surgery 103(4):101-107.

Klenner, F. (1953) The use of vitamin C as an antibiotic. Journal of Applied Nutrition 6:274-278.

Klenner, F. (April 1954) The treatment of trichinosis with massive doses of vitamin C and para-aminobenzoic acid. Tri-State Medical Journal pp. 25-30.

Klenner, F. (July 1954) Case history: cure of a 4-year-old child bitten by a mature highland moccasin with vitamin C. Tri-State Medical Journal .

Klenner, F. (July 1954) Recent discoveries in the treatment of lockjaw with vitamin C and Tolserol. Tri-State Medical Journal pp. 7-11.

Klenner, F. (November 1955) The role of ascorbic acid in therapeutics. (Letter to the Editor) Tri-State Medical Journal p. 34.

Klenner, F. (February 1956) A new office procedure for the determination of plasma levels for ascorbic acid. Tri-State Medical Journal pp. 26-28.

Klenner, F. (1971) Observations of the dose and administration of ascorbic acid when employed beyond the range of a vitamin in human pathology. Journal of Applied Nutrition 23(3&4):61-88.

Kline, A. and M. Eheart. (1944) Variation in the ascorbic acid requirements for saturation of nine normal young women. Journal of Nutrition 28:413-419.

Kligler, I. and H. Bernkopf. (1937) Inactivation of vaccinia virus by ascorbic acid and glutathione. Nature 139:965-966.

Kligler, L, L. Leibowitz, and M. Berman. (1937) The effect of ascorbic acid (vitamin C) on toxin production by C. Diphtheriae in culture media. Journal of Pathology 45:415-429.

Kligler, L, K. Guggenheim, and F. Warburg. (1938) Influence of ascorbic acid on the growth and toxin production of Cl. tetani and on the detoxication of tetanus toxin. Journal of Pathology 46: 619-629.

Knodell, R., M. Tate, B. Akl, and J. Wilson. (1981) Vitamin C prophylaxis for posttransfusion hepatitis: lack of effect in a controlled trial. American Journal of Clinical Nutrition 34(l):20-23.

Kobayashi, S., M. Takehana, S. Itoh, and E. Ogata. (1996) Protective effect of magnesium-L-ascorbyl-2 phosphate against skin damage induced by. UVB irradiation. Photochemistry and Photobiology 64(1): 224-228.

Kodavanti, U., G. Hatch, B. Starcher, S. Giri, D. Winsett, and D. Costa. (1995) Ozone-induced pulmonary functional, pathological, and biochemical changes in normal and vitamin C-deficient guinea pigs. Fundamental and Applied Toxicology 24(2):154-164.

Kodavanti, U., D. Costa, K. Dreher, K. Crissman, and G. Hatch. (1995a) Ozone-induced tissue injury and changes in antioxidant homeostasis in normal and ascorbate-deficient guinea pigs. Biochemical Pharmacology 50(2):243-251.

Kojima, S., H. lizuka, H. Yamaguchi, S. Tanuma, M. Kochi, and Y. Ueno. (1994) Antioxidative activity of benzylideneascorbate and its effect on adriamycin-induced cardiotoxicity. Anticancer Research 14(5A):1875-1880.

Kok, A. (1997) Ascorbate availability and neurodegeneration in amyotrophic lateral sclerosis. Medical Hypotheses 48(4):281-296.

Kola, I., R. Vogel, and H. Spielmann. (1989) Co-administration of ascorbic acid with cyclophosphamide (CFA) to pregnant mice inhibits the clastogenic activity of CFA in preimplantation murine blastocysts. Mutagenesis 4(4):297-301.

Konopacka, M., M. Widel, and J. Rzeszowska-Wolny. (1998) Modifying effect of vitamins C, E and beta-carotene against gamma-ray-induced DNA damage in mouse cells. Mutation Research 417(2-3):85-94.

Konopacka, M. and J. Rzeszowska-Wolny. (2001) Antioxidant vitamins C, E and beta-carotene reduce DNA damage before as well as after gamma-ray irradiation of human lymphocytes in vitro. Mutation Research 491(l-2):l-7.

Korallus, U., C. Harzdorf, and J. Lewalter. (1984) Experimental bases for ascorbic acid therapy of poisoning by hexavalent chromium compounds. International Archives of Occupational and Environmental Health 53(3):247-256.

Kodama, T. and T. Kojima. (1939) Studies of the staphylococcal toxin, toxoid and antitoxin; effect of ascorbic acid on staphylococcal lysins and organisms. Kitasato Archives of Experimental Medicine 16:36-55.

Koshiisi, I., Y. Mamura, and T. Imanari. (1997) Cyanate causes depletion of ascorbate in organisms. Biochimica et Biophysica Acta 1336(3)566-574.

Kromhout, D., B. Bloemberg, E. Feskens, A. Menotti, and A. Nissinen. (2000) Saturated fat, vitamin C and smoking predict long-term population ail-cause mortality rates in the Seven Countries Study. International Journal of Epidemiology 29(2):260-265.

Krasner, N., J. Dow, M. Moore, and A. Goldberg. (1974) Ascorbic-acid saturation and ethanol metabolism. Lancet 2(7882):693-695.

Kratzing, C. and R. Willis. (1980) Decreased levels of ascorbic acid in lung following exposure to ozone. Chemico-Biological Interactions 30(1)53-56.

Kretzschmar, C. and F. Ellis. (1974) The effect of x rays on ascorbic acid concentration in plasma and in tissues. The British Journal of Radiology 20(231):94-99.

Krishna, G., J. Nath, and T. Ong. (1986) Inhibition of cyclophosphamide and mitomycin C-induced sister chromatid exchanges in mice by vitamin C. Cancer Research 46(6):2670-2674.

Kraut, E., E. Metz, and A. Sagone. (1980) In vitro effects of ascorbate on white cell metabolism and the chemiluminescence response. Journal of the Reticuloendothelial Society 27(4):359-366.

Kubova, J., J. Tulinska, E. Stolcova, A. Mosat’ova, and E. Ginter. (1993) The influence of ascorbic acid on selected parameters of cell immunity in guinea pigs exposed to cadmium. Zeitschrift fur Ernahrungswissenschaft 32(2):113-120.

Kunert, K. and A. Tappel. (1983) The effect of vitamin C on in vivo lipid peroxidation in guinea pigs as measured by pentane and ethane production. Lipids 18(4):271-274.

Kurbacher, C, U. Wagner, B. Kolster, P. Andreotti, D. Krebs, and H. Bruckner. (1996) Ascorbic acid (vitamin C) improves the antineoplastic activity of doxorubicin, cisplatin, and paclitaxel in human breast carcinoma cells in vitro. Cancer Letters 103(2): 183-189.

Kulacz, R. and T. Levy. (2002) The Roots of Disease: Connecting Dentistry and Medicine. Philadelphia, PA: Xlibris Corporation.

Landwehr, R. (1991) The origin of the 42-year stonewall of vitamin C. Journal of Orthomolecular Medicine 6(2):99-103.

Landwehr, R. (1991) The origin of the 42-year stonewall of vitamin C. Journal of Orthomolecular Medicine 6(2):99-103.

Laky, D., S. Constantinescu, G. Filipescu, E. Ratea, and C. Zeana. (1984) Morphophysiological studies in experimental myocardial stress induced by isoproterenol. Note II. The myocardioprotector effect of magnesium ascorbate. Morphologie et Embryologie 30(1): 55-59.

Landauer, W. and D. Sopher. (1970) Succinate, glycerophosphate and ascorbate as sources of cellular energy and as antiteratogens. Journal of Embryology and Experimental Morphology 24(1):187-202.

Lauwerys, R., H. Roels, J. Buchet, A. Bernard, L. Verhoeven, and J. Konings. (1983) The influence of orally-administered vitamin C or zinc on the absorption of and the biological response to lead. Journal of Occupational Medicine 25(9):668-678.

Lamden, M. and G. Chrystowski. (1954) Urinary oxalate excretion by man following ascorbic acid ingestion. Proceedings of the Society for Experimental Biology and Medicine 85:190-192.

Lawton, J., L. Conway, J. Crosson, C. Smith, and P. Abraham. (1985) Acute oxalate nephropathy after massive ascorbic acid administration. Archives of Internal Medicine 145(5) :950-951.

Ledermann, E. (1962) Vitamin-C deficiency and ulceration of the face. The Lancet 2:1382.

Lee, E. (1991) Plant resistance mechanisms to air pollutants: rhythms in ascorbic acid production during growth under ozone stress.Chronobiology International 8(2):93-102.

Levine, M. (1986) New concepts in the biology and biochemistry of ascorbic acid. The New England Journal of Medicine 314(14): 892-902.

Lee, B., S. Lee, and H. Kim. (1998) Inhibition of oxidative DNA damage, 8-OhdG, and carbonyl contents in smokers treated with antioxidants (vitamin E, vitamin C, beta-carotene and red ginseng). Cancer Letters 132(l-2):219-227.

Lee, S. and I. Blair. (2001) Vitamin C-induced decomposition of lipid hydroperoxides to endogenous genotoxins. Science 292(5524):2083-2086.

Leveque, J. (1969) Ascorbic acid in treatment of the canine distemper complex. Veterinary Medicine/Small Animal Clinician 64(11):997-999,1001.

Levy, R. and F. Schlaeffer. (1993) Successful treatment of a patient with recurrent furunculosis by vitamin C: improvement of clinical course and of impaired neutrophil functions. International Journal of Dermatology 32(ll):832-834.

Levy, R., O. Shriker, A. Porath, K. Riesenberg, and F. Schlaeffer. (1996) Vitamin C for the treatment of recurrent furunculosis in patients with impaired neutrophil functions. The Journal of Infections Diseases 173(6):1502-1505.

Leung, H. and P. Morrow. (1981) Interaction of glutathione and ascorbic acid in guinea pig lungs exposed to nitrogen dioxide. Research Communications in Chemical Pathology and Pharmacology 31(1):111-118

Libowitkzy, O. and H. Seyfried. (1940) Bedeutung des vitamin C fur benzolarbeiter. Wein Klinische Wochenschrift 53:543.

Li, Y. and T. Lovell. (1985) Elevated levels of dietary ascorbic acid increase immune responses in channel catfish. The Journal of Nutrition 115(1):123-131.

Liehr, J. (1991) Vitamin C reduces the incidence and severity of renal tumors induced by estradiol or diethylstilbestrol. The American Journal of Clinical Nutrition 54(6 Suppl):1256S-1260S.

Longenecker, H., R. Musulin, R. Tully, and C. King. (1939) An acceleration of vitamin C synthesis and excretion by feeding known organic compounds to rats. The Journal of Biological Chemistry 129:445-453.

Longenecker, H., H. Fricke, and C. King. (1940) The effect of organic compounds upon vitamin C synthesis in the rat. The Journal of Biological Chemistry 135:492-510.

Loria, C., M. Klag, L. Caulfield, and P. Whelton. (2000) Vitamin C status and mortality in US adults. The American Journal of Clinical Nutrition 72(1):139-145.

Ludvigsson, J., L. Hansson, and O. Stendahl. (1979) The effect of large doses of vitamin C on leukocyte function and some laboratory parameters. International Journal of Vitamin and Nutrition Research 49(2):160-165.

Lund, C. and J. Crandon. (1941) Human experimental scurvy and the relation of vitamin C deficiency to postoperative pneumonia and wound healing. The Journal of the American Medical Association 116(8):663-668.

Lux, B. and P. May. (1983) Long-term observation of young cystinuric patients under ascorbic acid therapy. Urologia Internationalis 38(2):91-94.

Lurie, J. (1965) Benzene intoxication and vitamin C. The Transactions of the Association of Industrial Medical Officers 15:78-79.

Lyall, V., V. Chauhan, R. Prasad, A. Sarkar, and R. Nath. (1982) Effect of chronic chromium treatment on the ascorbic acid status of the rat. Toxicology Letters 12(2-3):131-135.

Magne, R. Vargas. (1963) Vitamin C in treatment of influenza. El Dia Medico 35:1714-1715.

Martin, G. and F. Heise. (1937) Vitamin C nutrition on pulmonary tuberculosis. American Journal of Digestive Diseases and Nutrition 4:368-373.

Maellaro, E., B. Del Bello, L. Sugherini, A. Pompella, A. Casini, and M. Comporti. (1994) Protection by ascorbic acid against oxidative injury of isolated hepatocytes. Xenobiotica 24(3):281-289.

Magos, L. and M. Sziza. (1962) Effect of ascorbic acid in aniline poisoning. Nature 194(4833):1084.

Massell, B., J. Warren, P. Patterson, and H. Lehmus. (1950) Antirheumatic activity of ascorbic acid in large doses. Preliminary observations on seven patients with rheumatic fever. The New England Journal of Medicine 242(16):614-615.

Matsuo, E., O. Skinsnes, and P. Chang. (1975) Acid mucopolysaccharide metabolism in leprosy. 3. Hyaluronic acid mycobacterial growth enhancement, and growth suppression by saccharic acid and vitamin C as inhibitors of 8-glucuronidase. International Journal of Leprosy and Other Mycobacterial Diseases 43(1):1-13.

Majewska, M. and J. Bell. (1990) Ascorbic acid protects neurons from injury induced by glutamate and NMDA. Neuroreport 1(3-4):194-196.

Marchmont-Robinson, S. (1941) Effect of vitamin C on workers exposed to lead dust. Journal of laboratory and Clinical Medicine 26:1478-1481.

Mavin, J. (1941) Experimental treatment of acute mercury poisoning of guinea pigs with ascorbic acid. Revista de la Sociedad Argentina de Biologia (Buenos Aires) 17:581-586.

Marva, E., J. Golenser, A. Cohen, N. Kitrossky, R. Har-El, and M. Chevion. (1992) The effects of ascorbate-induced free radicals on Plasmodium falciparum. Tropical Medicine and Parasitology 43(1)317-23.

Mashour, S., J. Turner, and R. Merrell. (2000) Acute renal failure, oxalosis, and vitamin C supplementation. Chest 118(2)561-563.

Maritz, G. (1993) The influence of maternal nicotine exposure on neonatal lung metabolism. Protective effect of ascorbic acid. Cell Biology International 17(6):579-585.

Matkovics, B., K. Barabas, L. Szabo, and G. Berencsi. (1980) In vivo study of the mechanism of protective effects of ascorbic acid and reduced glutathione in paraquat poisoning. General Pharmacology 11(5):455-461.

Matsuki, Y., M. Akazawa, K. Tsuchiya, H. Sakurai, H. Kiwada, and T. Goromaru. (1991) [Effects of ascorbic acid on the free radical formations of isoniazid and its metabolites]. Article in Japanese. Yakugaku Zasshi. Journal of the Pharmaceutical Society of Japan 111(10):600-605.

Matsuki, Y., Y. Hongu, Y. Noda, H. Kiwada, H. Sakurai, and T. Goromaru. (1992) [Effects of ascorbic acid on the metabolic fate and the free radical formation of iproniazid]. Article in Japanese. Yakugaku Zasshi. Journal of the Pharmaceutical Society of Japan. 112(12):926-933.

Matsuki, Y., R. Bandou, H. Kiwada, H. Maeda, and T. Goromaru. (1994) Effects of ascorbic acid on iproniazid-induced hepatitis in phenobarbital-treated rats. Biological & Pharmaceutical Bulletin 17(8):1078-1082.

Matsushita, N., T. Kobayashi, H. Oda, F. Horio, and A. Yoshida. (1993) Ascorbic acid deficiency reduces the level of mRNA for cytochrome P-450 on the induction of polychlorinated biphenyls. Journal of Nutritional Science and Vitaminology 39(4):289-302.

Marva, E., A. Cohen, P. Saltman, M. Chevion, and J. Golenser. (1989) Deleterious synergistic effects of ascorbate and copper on the development of Plasmodium falciparum: an in vitro study in normal and in G6PD-deficient erythrocytes. International Journal of Parasitology 19(7):779-785.

Marva, E., J. Golenser, A. Cohen, N. Kitrossky, R. Har-el, and M. Chevion. (1992) The effects of ascorbate-induced free radicals on Plasmodium falciparum. Tropical Medicine and Parasitology 43(1): 17-23.

Massell, B., J. Warren, P. Patterson, and H. Lehmus. (1950) Antirheumatic activity of ascorbic acid in large doses. Preliminary observations on seven patients with rheumatic fever. The New England Journal of Medicine 242(16):614-615.

McConkey, M. and D. Smith. (1933) The relation of vitamin C deficiency to intestinal tuberculosis in the guinea pig. Journal of Experimental Mediane 58:503-512.

McCormick, W. (1951) Vitamin C in the prophylaxis and therapy of infectious diseases. Archives of Pediatrics 68(l):l-9.

McCullough, N. (1938) Vitamin C and resistance of the guinea pig to infection with Bacterium necrophorum. The Journal of Infectious Diseases 63:34-53.

McKee, R. and Q. Geiman. (1946) Studies on malarial parasites. V. Effects of ascorbic acid on malaria (Plasmodium knowlesi) in monkeys. Proceedings of the Society for Experimental Biology and Medicine 63:313-315.

McChesney, E. (1945) Further studies on the detoxication of the arsphenamines by ascorbic acid. The Journal of Pharmacology and Experimental Therapeutics 84:222-235.

McConnico, R. and C. Brownie. (1992) The use of ascorbic acid in the treatment of 2 cases of red maple (Acer rubrum)-poisoned horses. The Cornell Veterinarian 82(3):293-300.

McCormick, W. (1945) Sulfonamide sensitivity and C-avitaminosis Canadian Medical Association Journal 52:68-70.

McAllister, C., E. Scowden, F. Dewberry, and A. Richman. (1984) Renal failure secondary to massive infusion of vitamin C. The Journal of the American Medical Association 252(13):1684.

McKeown-Eyssen, G., C. Holloway, V. Jazmaji, E. Bright-See, P. Dion, and W. Bruce. (1988) A randomized trial of vitamins C and E in the prevention of recurrence of colorectal polyps. Cancer Research 48(16):4701-4705.

McLaran, C., J. Bett, J. Nye, and J. Halliday. (1982) Congestive cardiomyopathy and haemochromatosis-rapid progression possibly accelerated by excessive ingestion of ascorbic acid. Australian and New Zealand Journal of Medicine 12(2):187-188.

Meiklejohn, A. (1953) The physiology and biochemistry of ascorbic acid. Vitamins and Hormones 11:61-96.

Melethil, S., D. Mason, and C. Chang. (1986) Dose-dependent absorption and excretion of vitamin C in humans. International Journal of Pharmacology 31:83-89.

Meier, K. (1945) Vitamin C treatment of pertussis. Annales de Pédiatrie (Paris) 164:50-53.

Mena, M., B. Pardo, C. Paino, and J. de Yebenes. (1993) Levodopa toxicity in foetal rat midbrain neurons in culture: modulation by ascorbic acid. Neuroreport 4(4):438-440.

Miller, T. (1969) Killing and lysis of gram-negative bacteria through the synergistic effect of hydrogen peroxide, ascorbic acid, and lysozyme. Journal of Bacteriology 98(3):949-955.

Milner, J. (1980) Ascorbic acid in the prevention of chromium dermatitis. Journal of Occupational Medicine 22(1)51-52.

Minakata, K., O. Suzuki, S. Saito, and N. Harada. (1993) Ascorbate radical levels in human sera and rat plasma intoxicated with paraquat and diquat. Archives of Toxicology 67(2):126-130.

Minakata, K., O. Suzuki, S. Saito, and N. Harada. (1996) Effect of dietary paraquat on a rat mutant unable to synthesize ascorbic acid. Archives of Toxicology 70(3-4):256-258.

Miquel, M., M. Aguilar, and C. Aragon. (1999) Ascorbic acid antagonizes ethanol-induced locomotor activity in the open-field. Pharmacology, Biochemistry, and Behavior 62(2):361-366.

Mireles-Rocha, H., I. Galindo, M. Huerta, B. Trujillo-Hernandez, A. Elizalde, and R. Cortes-Franco. (2002) UVB photoprotection with antioxidants: effects of oral therapy with d-alpha-tocopherol and ascorbic acid on the minimal erythema dose. Acta Dermato-Venereologica 82(l):21-24.

Mitra, A., A. Kulkarni, V. Ravikumar, and D. Bourcier. (1991) Effect of ascorbic acid esters on hepatic glutathione levels in mice treated with a hepatotoxic dose of acetaminophen. Journal of Biochemical Toxicology 6(2):93-100.

Miyai, E., M. Yanagida, J. Akiyama, and I. Yamamoto. (1996) Ascorbic acid 2-O-alpha-glucoside, a stable form of ascorbic acid, rescues human keratinocyte cell line, SCC, from cytotoxicity of ultraviolet light B. Biological & Pharmaceutical Bulletin 19(7):984-987.

Mizushima, Y., T. Harauchi, T. Yoshizaki, and S. Makino. (1984) A rat mutant unable to synthesize vitamin C. Experientia 40(4): 359-361.

Mizutani, A., H. Maki, Y. Torii, K. Hitomi, and N. Tsukagoshi. (1998) Ascorbate-dependent enhancement of nitric oxide formation in activated macrophages. Nitric Oxide: Biology and Chemistry 2(4): 235-241.

Mizutani, A. and N. Tsukagoshi. (1999) Molecular role of ascorbate in enhancement of NO production in activated macrophage-like cell line, J774.1. Journal of Nutritional Science and Vitaminology 45(4): 423-435.

Moertel, C., T. Fleming, E. Creagan, J. Rubin, M. O’Connell, and M. Ames. (1985) High-dose vitamin C versus placebo in the treatment of patients with advanced cancer who have had no prior chemotherapy. A randomized double-blind comparison. The New England Journal of Medicine 312(3):137-141.

Mochizuki, H., H. Oda, and H. Yokogoshi. (2000) Dietary taurine alters ascorbic acid metabolism in rats fed diets containing polychlorinated biphenyls. The Journal of Nutrition 130(4):873-876.

Moison, R. and G. Beijersbergen van Henegouwen. (2002) Topical antioxidant vitamins C and E prevent UVB-radiation-induced peroxidation of eicosapentaenoic acid in pig skin. Radiation Research 157(4):402-409.

Mohr, W. (1941) Vitamin C-stoffwechsel und malaria. [Malaria and assimilation of vitamin C] Deut Trop Zeitschrift 45(13):404-405. Also cited in: (1943) Tropical Diseases Bulletin 40(1):13-14.

Morishige, F. and A. Murata. (1978) Vitamin C for prophylaxis of viral hepatitis B in transfused patients. Journal of the International Academy of Preventive Medicine 5(1):54-58.

Mouriquand, G., A. Dochaix, and L. Dosdat. (1925) Tuberculose virulente et avitaminose C. Compt Rend Soc Biol 93:901.

Mokranjac, M. and C. Petrovic. (1964) Vitamin C as an antidote in poisoning by fatal doses of mercury. Comptes Rendus Hebdomadaires des Séances de l’Académie des Sciences 258:1341-1342.

Moldowan, M. and W. Acholonu. (1982) Effect of ascorbic acid or thiamine on acetaldehyde, disulfiram-ethanol- or disulfiram-acetaldehyde-induced mortality. Agents and Actions 12(5-6):731-736.

Mothersill, C., J. Malone, and M. O’Connor. (1978) Vitamin C and radioprotection. British Journal of Radiology 51(606):474.

Mulholland, C., J. Strain, and T. Trinick. (1996) Serum antioxidant potential, and lipoprotein oxidation in female smokers following vitamin C supplementation. International Journal of Food Sciences and Nutrition 47(3):227-231.

Mueller, K. and P. Kunko. (1990) The effects of amphetamine and pilocarpine on the release of ascorbic and uric acid in several rat brain areas. Pharmacology, Biochemistry, and Behavior 35(4):871-876.

Murray, D. and R. Hughes. (1976) The influence of dietary ascorbic acid on the concentration of mercury in guinea-pig tissues. The Proceedings of the Nutrition Society 35(3):118A-119A.

Murphy, B., J. Krushak, J. Maynard, and D. Bradley. (1974) Ascorbic acid (vitamin C) and its effects on parainfluenza type III virus infection in cotton-topped marmosets. Laboratory Animal Science 24(l):229-232.

Myrvik, Q., R. Weiser, B. Houglum, and L. Berger. (1954) Studies on the tuberculoinhibitory properties of ascorbic acid derivatives and their possible role in inhibition of tubercle bacilli by urine. American Review of Tuberculosis 69:406-418.

Nandi, B., N. Subramanian, A. Majumder, and I. Chatterjee. (1974) Effect of ascorbic acid on detoxification of histamine under stress conditions. Biochemical Pharmacology 23(3):643-647.

Nagaoka, S., .H. Kamuro, H. Oda, and A. Yashida. (1991) Effects of polychlorinated biphenyls on cholesterol and ascorbic acid metabolism in primary cultured rat hepatocytes. Biochemical Pharmacology 41(8):1259-1261.

Nagyova, A., S. Galbavy, and E. Ginter. (1994) Histopathological evidence of vitamin C protection against Cd-nephrotoxicity in guinea pigs. Experimental and Toxicologie Pathology 46(1):11-14.

Nagyova, A. and E. Ginter. (1995) The influence of ascorbic acid on the hepatic cytochrome P-450, and glutathione in guinea-pigs exposed to 2,4-dichlorophenol. Physiological Research 44(5):301-305.

Nakagawa, Y., I. Cotgreave, and P. Moldeus. (1991) Relationships between ascorbic acid and alpha-tocopherol during diquat-induced redox cycling in isolated rat hepatocytes. Biochemical Pharmacology 42(4):883-888.

Nakao, S. (1961) Studies on the accelerating effect of cyanide on ascorbic acid oxidation by intestinal homogenate of rats. Japanese Journal of Pharmacology 10:101-108.

Nardini, M., E. Finkelstein, S. Reddy, G. Valacchi, M. Traber, C. Cross, and A. van der Vliet. (2002) Acrolein-induced cytotoxiciry in cultured human bronchial epithelial cells. Modulation by alpha-tocopherol and ascorbic acid. Toxicology 170(3):173-185.

Narra, V., R. Howell, K. Sastry, and D. Rao. (1993) Vitamin C as a radioprotector against iodine-131 in vivo. Journal of Nuclear Medicine 34(4):637-640.

Nefic, H. (2001) Anticlastogenic effect of vitamin C on cisplatin induced chromosome aberrations in human lymphocyte cultures. Mutation Research 498(l-2):89-98.

Nelson, J., J. Alexander, P. Jacobs, R. Ing, and C. Ogle. (1992) Metabolic and immune effects of enterai ascorbic acid after burn trauma., Burns: Journal of the International Society for Burn Injuries 18(2):92-97.

Netke, S., M. Roomi, C. Tsao, and A. Niedzwiecki. (1997) Ascorbic acid protects guinea pigs from acute aflatoxin toxicity. Toxicology and Applied Pharmacology 143(2):429-435.

Neumann, N., E. Holzle, M. Wallerand, S. Vierbaum, T. Ruzicka, and P. Lehmann. (1999) The photoprotective effect of ascorbic acid, acetylsalicylic acid, and indomethacin evaluated by the photo hen’s egg test. Photodermatology, Photoimmunology & Photomedicine 15(5):166-170.

Niazi, S., J. Lim, and J. Bederka. (1982) Effect of ascorbic acid on renal excretion of lead in the rat. Journal of Pharmaceutical Sciences 71(10): 1189-1190.

Nienhuis, A. (1981) Vitamin C and iron. The New England Journal of Medicine 304(3):170-171.

Njoku, O., I. Ononogbu, D. Nwachukwu. (1995) Plasma cholesterol, 6-carotene and ascorbic acid changes in human malaria. The Journal of Communicable Diseases 27(3):186-190.

Nowak, G., C. Carter, and R. Schnellmann. (2000) Ascorbic acid promutes recovery of cellular functions following toxicant-induced injury. Toxicology and Applied Pharmacology 167(l):37-45.

Nungester, W. and A. Ames. (1948) The relationship between ascorbic acid and phagocytic activity. Journal of Infections Diseases 83:50-54.

Nyyssonen, K., H. Poulsen, M. Hayn, P. Agerbo, E. Porkkala-Sarataho, J. Kaikkonen, R. Salonen, and J. Salonen. (1997) Effect of supplementation of smoking men with plain or slow release ascorbic acid on lipoprotein oxidation. European Journal of Clinical Nutrition 51(3):154-163.

Oberritter, H., B. Glatthaar, U. Moser, and K. Schmidt. (1986) Effect of functional stimulation on ascorbate content in phagocytes under physiological and pathological conditions. International Archives ofAllergy and Applied Immunology 81(1):46-50.

O’Brien, R. (1974) Ascorbic acid enhancement of desferrioxamine-induced urinary iron excretion in thalassemia major. Annals of the New York Academy of Sciences 232:221-225.

Oda, H., K. Yamashita, S. Sasaki, F. Horio, and A. Yoshida. (1987) Long-term effects of dietary polychlorinated biphenyl and high level of vitamin E on ascorbic acid and lipid metabolism in rats. The Journal of Nutrition 117(7):1217-1223.

Odumosu, A. and C. Wilson. (1973) Metabolic availability of vitamin C in the guinea-pig. Nature 242(5399):519-521.

Okunieff, P. (1991) Interactions between ascorbic acid and the radiation of bone marrow, skin, and tumor. The American Journal of Clinical Nutrition 54(6 Suppl):1281S-1283S.

Olas, B., B. Wachowicz, and A. Buczynski. (2000) Vitamin C suppresses the cisplatin toxicity on blood platelets. Anti-cancer Drugs 11(6):487-493.

On, Y., H. Kim, S. Kim, I. Chae, B. Oh, M. Lee, Y. Park, Y. Choi, and M. Chung. (2001) Vitamin C prevents radiation-induced endothelium-dependent vasomotor dysfunction and de-endothelialization by inhibiting oxidative damage in the rat. Clinical and Experimental Pharmacology & Physiology 28(10):816-821.

Orens, S. (1983) Hepatitis B-a ten day cure: a personal history. Bulletin Philadelphia City Dental Society 48(6):4-5.

Ormerod, M. and B. Unkauf. (1937) Ascorbic acid (vitamin C) treatment of whooping cough. Canadian Medical Association Journal 37(2):134-136.

Ormerod, M., B. Unkauf, and F. White. (1937) A further report on the ascorbic acid treatment of whooping cough. Canadian Medical Association Journal 37(3):268-272.

Osilesi, O., L. Trout, J. Ogunwole, and E. Glover. (1991) Blood pressure and plasma lipids during ascorbic acid supplementation in borderline hypertensive and normotensive adults. Nutrition Research 11:405-412.

Osborn, T. and J. Gear. (1940) Possible relation between ability to synthesize vitamin C and reaction to tubercle bacillus. Nature 145: 974.

Otero, P, M. Viana, E. Herrera, and B. Bonet. (1997) Antioxidant and prooxidant effects of ascorbic acid, dehydroascorbic acid and flavonoids on LDL submitted to different, degrees of oxidation. Free Radical Research 27(6):619-626.

Ott, S., D. Andress, and D. Sherrard. (1986) Bone oxalate in a long-term hemodialysis patient who ingested high doses of vitamin C. American Journal of Kidney Diseases 8(6):450-454.

Otani, T. (1936) On the vitamin C therapy of pertussis. Klinische Wochenschrift 15(51):1884-1885.

Otani, T. (1939) Influence of vitamin C (L-ascorbic acid) upon the whooping cough bacillus and its toxin. Oriental Journal of Diseases of Infants 25:1-4.

Paez de la Torre, J. (1945) Ascorbic acid in measles. Archives Argentinos de Pediatria 24:225-227.

Pakter, J. and B. Schick. (1938) Influence of vitamin C on diphtheria toxin. American Journal of Diseases of Children 55:12-26.

Panush, R., J. Delafuente, P. Katz, and J. Johnson. (1982) Modulation of certain immunologie responses by vitamin C. III. Potentiation of in vitro and in vivo lymphocyte responses. International Journal for Vitamin and Nutrition Research. Supplement 23:35-47.

Pandya, K., G. Singh, and N. Joshi. (1970) Effect of benzanthrone on the body level of ascorbic acid in guinea pigs. Acta Pharmacologica et Toxicologica 28(6):499-506.

Pardo, B., M. Mena, S. Fahn, and J. de Yebenes. (1993) Ascorbic acid protects against levodopa-induced neurotoxicity on a catecholine-rich human neuroblastoma cell line. Movement Disorders 8(3):278-284.

Paolini, M., L. Pozzetti, G. Pedulli, E. Marchesi, and G. Cantelli-Forti. (1999) The nature of prooxidant activity of vitamin C. Life Sciences 64(23):PL-273-PL-278.

Patrone, F., F. Dallegri, E. Bonvini, F. Minervini, and C. Sacchetti. (1982) Effects of ascorbic acid on neutrophil function. Studies on normal and chronic granulomatous disease neutrophils. Acta Vitaminologica et Enzymologica 4(1-2):163-168.

Pauling, L. (1970) Vitamin C and the Common Cold. San Francisco, CA: W.H. Freeman and Company.

Pauling, L. (1981) Vitamin C, the Common Cold & the Flu. New York, NY: Berkley Books.

Peloux, Y., C. Lofre, A. Cier, and A. Colobert. (1962) Inactivation du virus polio-myélitique par des systèmes chimique générateurs du radical libre hydroxide. Méchanisme de l’activité virulicide du peroxyde d’hydrogène et de l’acide ascorbique. Annls Inst Pasteur, Paris 102:6.

Perla, D. (1937) The effect of an excess of vitamin C on the natural resistance of mice and guinea pigs to trypanosome infections. American Journal of Hygiène 26:374-381.

Petter, C. (1937) Vitamin C and tuberculosis. The Journal-Lancet (Minneapolis) 57:221-224.

Perez, A., S. Fernandez, M. Garcia-Roche, A. de las Cagigas, A. Castillo, G. Fonseca, and M. Herrera. (1990) Mutagenicity of N-nitrosomorpholine biosynthesized from morpholine in the presence of nitrate and its inhibition by ascorbic acid. Die Nahrung 34(7):661-664.

Perminova, L, T. Sinel’shchikova, N. Alekhina, E. Perminova, and G. Zasukhina. (2001) Individual sensitivity to genotoxic effects of nickel and antimutagenic activity of ascorbic acid. Bulletin of Experimental Biology and Medicine 131(4):367-370.

Peterson, F. and R. Knodell. (1984) Ascorbic acid protects against acetaminophen- and cocaine-induced hepatic damage in mice. Drug-Nutrient Interactions 3(1):33-41.

Pijoan, M. and E. Lozner. (1944) Vitamin C economy in the human subject. Bulletin of the johns Hopkins Hospital 75:303-314.

Pillans, P., S. Ponzi, and M. Parker. (1990) Effects of ascorbic acid on the mouse embryo and on cyclophosphamide-induced cephalic DNA strand breaks in vivo. Archives of Toxicology 64(5):423-425.

Pillemer, L., J. Seifter, A. Kuehn, and E. Ecker. (1940) Vitamin C in chronic lead poisoning. An experimental study. The American Journal of the Medical Sciences 200:322-327.

Pijoan, M. and B. Sedlacek. (1943) Ascorbic acid in tuberculous Navajo Indians. American Review of Tuberculosis 48:342-346.

Pitt, H. and A. Costrini. (1979) Vitamin C prophylaxis in marine recruits. Journal of the American Medical Association 241(9):908-911.

Pirozzi, D., P. Gross, and M. Samitz. (1968) The effect of ascorbic acid on chrome ulcers in guinea pigs. Archives of Environmental Health 17(2):178-180.

Plit, M., A. Theron, H. Fickl, C. van Rensbury, S. Pendel, and R. Anderson. (1998) Influence of antimicrobial chemotherapy and smoking status on the plasma concentrations of vitamin C, vitamin E, beta-carotene, acute phase reactants, iron and lipid peroxides in patients with pulmonary tuberculosis. The International Journal of Tuberculosis and Lung Disease 2(7):590-596.

Podmore, L, H. Griffiths, K. Herbert, N. Mistry, P. Mistry, and J. Lunee. (1998) Vitamin C exhibits pro-oxidant properties. Nature 392(6676):559.

Polec, R., S. Yeh, and M. Shils. (1971) Protective effect of ascorbic acid, isoascorbic acid and mannitol against tetracycline-induced nephrotoxicity. The Journal of Pharmacology and Experimental Therapeutics 178(1):152-158.

Poon, R., I. Chu, P. Lecavalier, A. Bergman, and D. Villeneuve. (1994) Urinary ascorbic acid-HPLC determination and application as a noninvasive biomarker of hepatic response. Journal of Biochemical Toxicology 9(6):297-304.

Ponka, A. and B. Kuhlback. (1983) Serum ascorbic acid in patients undergoing chronic hemodialysis. Acta Medica Scandinavica 213(4):305-307.

Prieme, H., S. Loft, K. Nyyssonen, J. Salonen, and H. Poulsen. (1997) No effect of supplementation with vitamin E, ascorbic acid, or coenzyme Q10 on oxidative DNA damage estimated by 8-oxo-7,8-dihydro-2′-deoxyguanosine excretion in smokers. The American Journal of Clinical Nutrition 65(2):503-507.

Pru, C, J. Eaton, and C. Kjellstrand. (1985) Vitamin C intoxication and hyperoxalemia in chronic hemodialysis patients. Nephron 39(2):112-116.

Prinz, W., R. Bortz, B. Bregin, and M. Hersch. (1977) The effect of ascorbic acid supplementation on some parameters of the human immunological defence System. International Journal for Vitamin and Nutrition Research 47(3):248-257.

Radford, M., E. de Savitsch, and H. Sweany. (1937) Blood changes following continuous daily administration of vitamin C and orange juice to tuberculous patients. American Review of Tuberculosis 35:784-793.

Rai, L. and M. Raizada. (1988) Impact of chromium and lead on Nostoc muscorum: regulation of toxicity by ascorbic acid, glutathione, and sulfur-containing amino acids. Ecotoxicology and Environmental Safety 15(2):195-205.

Raina, V. and H. Gurtoo. (1985) Effects of vitamins A, C, and E on aflatoxin B1-induced mutagenesis in Salmonella typhimurium TA-98 and TA-100. Teratogenesis, Carcinogenesis, and Mutagenesis 5(1): 29-40.

Rajini, P. and M. Krishnakumari. (1985) Effect of L-ascorbic acid supplementation on the toxicity of pirimiphos-methyl to albino rats. International Journal for Vitamin and Nutrition Research 55(4): 421-424.

Rambeck, W. and I. Guillot. (1996) [Bioavailability of cadmium: effect of vitamin C and phytase in broiler chickens]. Article in German. Tierarztliche Praxis 24(5):467-470.

Ramos, K. and D. Acosta. (1983) Prevention by L(-)ascorbic acid of isoproterenol-induced cardiotoxicity in primary cultures of rat myocytes. Toxicology 26(1):81-90.

Rawal, B. (1978) Bactericidal action of ascorbic acid on Pseudomonas aeruginosa: alteration of cell surface as a possible mechanism. Chemotherapy 24(3):166-171.

Raziq, F. and N. Jafarey. (1987) Influence of vitamin C administered after radiation. The Journal of the Pakistan Medical Association 37(3):70-72.

Ramirez, L., E. Lages-Silva, G. Pianetti, R. Rabelo, J. Bordin, and H. Moraes-Souza. (1995) Prevention of transfusion-associated Chagas disease by sterilization of Trypanosoma cruzi-infected blood with gentian violet, ascorbic acid, and light. Transfusion 35(3):226-230.

Rawal, B. and B. Charles. (1972) Inhibition of Pseudomonas aeruginosa by ascorbic acid-sulphamethoxazole-trimethoprim combination. The Southeast Asian Journal of Tropical Medicine and Public Health 3(2):225-228.

Rawal, B., F. Bartolini, and G. Vyas. (1995) In vitro inactivation of human immunodeficiency virus by ascorbic acid. Biologicals 23(1):75-81.

Rawal, B., G. McKay, and M. Blackhall. (1974) Inhibition of Pseudomonas aeruginosa by ascorbic acid acting singly and in combination with antimicrobials: in-vitro and in-vivo studies. Medical Journal ofAustralia 1(6):169-174.

Rawal, B. (1978) Bactericidal action of ascorbic acid on Pseudomonas aeruginosa: alteration of cell surface as a possible mechanism. Chemotherapy 24(3):166-171.

Rebec, G., J. Centore, L. White, and K. Alloway. (1985) Ascorbic acid and the behavioral response to haloperidol: implications for the action of antipsychotic drugs. Science 227(4685):438-440.

Reddy, G. and S. Srikantia. (1971) Effect of dietary calcium, vitamin C and protein in development of experimental skeletal fluorosis. I. Growth, serum chemistry, and changes in composition, and radiological appearance of bones. Metabolism 20(7):642-656.

Reddy, V., F. Giblin, L. Lin, and B. Chakrapani. (1998) The effect of aqueous humor ascorbate on ultraviolet-B-induced DNA damage in lens epithelium. Investigative Ophthalmology & Visual Science 39(2):344-350.

Rees, D., H. Kelsey, and J. Richards. (1993) Acute haemolysis induced by high dose ascorbic acid in glucose-6-phosphate dehydrogenase deficiency. BMJ 306(6881):841-842.

Rees, S. and T. Slàter. (1987) Ascorbic acid and lipid peroxidation: the cross-over effect. Acta Biochimica et Biophysica Hungarica 22: 241-249.

Rehman, A., C. Collis, M. Yang, M. Kelly, A. Diplock, B. Halliwell, and C. Rice-Evans. (1998) The effects of iron and vitamin C co-supplementation on oxidative damage to DNA in healthy volunteers. Biochemical and Biophysical Research Communications 246(l):293-298.

Rifici, V. and A. Khachadurian. (1993) Dietary supplementation with vitamins C and E inhibits in vitro oxidation of lipoproteins. Journal of the American College of Nutrition 12(6):631-637.

Rinehart, J. (1936) An outline of studies relating to vitamin C deficiency in rheumatic fever. The Journal of Laboratory and Clinical Medicine 21:597-608.

Rinehart, J., L. Greenberg, and A. Christie. (1936) Reduced ascorbic acid content of blood plasma in rheumatic fever. Proceedings of the Society for Experimental Biology and Medicine 35(2):350-353.

Rinehart, J., L. Greenberg, M. Olney, and F. Choy. (1938) Metabolism of vitamin C in rheumatic fever. Archives of Internal Medicine 61: 552-561.

Rivas, C., J. Vera, V. Guaiquil, F. Velasques, O. Borquez-Ojeda, J. Carcamo, I. Concha, and D. Golde. (1997) Increased uptake and accumulation of vitamin C in human immunodeficiency virus 1-infected hematopoietic cell lines. Journal of Biological Chemistry 272(9)5814-5820.

Riordan, H., J. Jackson, and M. Schultz. (1990) Case study: high-dose intravenous vitamin C in the treatment of a patient with adenocarcinoma of the kidney. Journal of Orthomolecular Medicine 5(l):5-7.

Riordan, H., H. Riordan, X. Meng, Y. Li, and J. Jackson. (1995) Intravenous ascorbate as a tumor cytotoxic chemotherapeutic agent. Medical Hypotheses 44(3):207-213.

Riordan, N., J. Jackson, and H. Riordan. (1996) Intravenous vitamin C in a terminal cancer patient. Journal of Orthomolecular Medicine ll(2):80-82.

Rojas, C., S. Cadenas, A. Herrero, J. Mendez, and G. Barja. (1996) Endotoxin depletes ascorbate in the guinea pig heart. Protective effects of vitamins C and E against oxidative stress. Life Sciences 59(8):649-657.

Robertson, W., M. Ropes, and W. Bauer. (1941) The degradation of mucins and polysaccharides by ascorbic acid and hydrogen peroxide. The Biochemical Journal 35:903.

Rotman, D. (1978) Sialoresponsin and an antiviral action of ascorbic acid. Medical Hypotheses 4(l):40-43.

Romero-Ferret, C., G. Mottot, J. Legros, and G. Margetts. (1983) Effect of vitamin C on acute paracetamol poisoning. Toxicology Letters 18(1-2):153-156.

Rothe, S., J. Gropp, H. Weiser, and W. Rambeck. (1994) [The effect of vitamin C and zinc on the copper-induced .increase of cadmium residues in swine]. Article in German. Zeitschrift fur Ernahrungswissenshaft 33(l):61-67.

Roy, A., H. Dhir, and A. Sharma. (1992) Modification of metal-induced micronuclei formation in mouse bone marrow erythrocytes by Phyllanthus fruit extract and ascorbic acid. Toxicology Letters 62(1):9-17.

Rose, R. and A. Bode. (1992) Tissue-mediated regeneration of ascorbic acid: is the process enzymatic? Enzyme 46(4-5):196-203.

Rowbotham, B. and H. Roeser. (1984) Iron overload associated with congenital pyruvate kinase deficiency and high dose ascorbic acid ingestion. Australian and New Zealand Journal of Medicine 14(5):667-669.

Rudra, P., J. Chatterjee, and G. Chatterjee. (1975) Influence of lead administration on L-ascorbic acid metabolism in rats: effect of L-ascorbic acid supplementation. International Journal for Vitamin and Nutrition Research 45(4):429-437.

Rudra, M. and S. Roy. (1946) Haematological study in pulmonary tuberculosis and the effect upon it of large doses of vitamin C. Tubercle 27:93-94.

Ruskin, S. and R. Silberstein. (1938) Practical therapeutics. The influence of vitamin C on the therapeutic activity of bismuth, antimony and the arsenic group of metals. Medical Record 153:327-330.

Ruskin, A. and J. Johnson. (1949) Cardiodepressive effects of mercurial diuretics. Cardioprotective value of BAL, ascorbic acid and thiamin. Proceedings of the Society for Experimental Biology and Medicine 72:577-583.

Ruskin, A. and B. Ruskin. (1952) Effect of mercurial diuretics upon the respiration of the rat heart and kidney. III. The protective action of ascorbic acid against Mercuhydrin in vitro. Texas Reports on Biology and Medicine 10:429-438.

Sabin, A. (1939) Vitamin C in relation to experimental poliomyelitis with incidental observations on certain manifestations in Macacus rhesus monkeys on a scorbutic diet. Journal of Experimental Medicine 69:507-515.

Sadun, E., J. Bradin, Jr., and E. Faust. (1951) The effect of ascorbic acid deficiency on the resistance of guinea-pigs to infection with Endamoeba histolytica of human origin. American Journal of Tropical Medicine 31:426-437.

Salem, M., K. Kamel, M. Yousef, G. Hassan, and F. El-Nouty. (2001) Protective role of ascorbic acid to enhance semen quality of rabbits treated with sublethal doses of aflatoxin B(l). Toxicology 162(3): 209-218.

Samitz, M. and S. Katz. (1965) Protection against inhalation of chromic acid mist. Use of filters impregnated with ascorbic acid. Archives of Environmental Health 11(6):770-772.

Samitz, M., D. Scheiner, and S. Katz. (1968) Ascorbic acid in the prevention of chrome dermatitis. Mechanism of inactivation of chromium. Archives of Environmental Health 17(l):44-45.

Samitz, M. (1970) Ascorbic acid in the prevention and treatment of toxic effects from chromates. Acta Dermato-Venereologica 50(1): 59-64.

Samman, S., A. Brown, C. Beltran, and S. Singh. (1997) The effect of ascorbic acid on plasma lipids and oxidisability of LDL in male smokers. European Journal of Clinical Nutrition 51(7):472-477.

Sanchez-Quesada, J., O. Jorba, A. Payes, C. Otal, R. Serra-Grima, F. Gonzalez-Sastre, and J. Ordonez-Llanos. (1998) Ascorbic acid inhibits the increase in low-density lipoprotein (LDL) susceptibility to oxidation and the proportion of electronegative LDL induced by intense aerobic exercise. Coronary Artery Disease 9(5):249-255.

Sandoval, M., X. Zhang, X. Liu, E. Mannick, D. Clark, and M. Miller. (1997) Peroxynitrite-induced apoptosis in T84 and RAW 264.7 cells: attenuation by L-ascorbic acid. Free Radical Biology & Medicine 22(3):489-495.

Sarma, L. and P. Kesavan. (1993) Protective effects of vitamins C and E against gamma-ray-induced chromosomal damage in mice. International Journal of Radiation Biology 63(6):759-764.

Sahu, K. and R. Das. (1994) Reduction of clastogenic effect of clofazimine, an antileprosy drug, by vitamin A and vitamin C in bone marrow cells of mice. Food and Chemical Toxicology 32(10): 911-915.

Sakamoto, M., S. Kobayashi, S. Ishii, K. Katoo, and N. Shimazono. (1981) The effect of vitamin C deficiency on complement systems and complement components. Journal of Nutritional Science and Vitaminology 27(4):367-378.

Schmidt, K., V. Hagmaier, D. Hornig, J. Vuilleumier, and G. Rutishauser. (1981) Urinary oxalate excretion after large intakes of ascorbic acid in man. American Journal of Clinical Nutrition 34(3):305-311.

Schwille, P., A. Schmiedl, U. Herrmann, M. Manoharan, J. Fan, V. Sharma, and D. Gottlieb. (2000) Ascorbic acid in idiopathic recurrent calcium urolithiasis in humans-does it have an abettor role in oxalate, and calcium oxalate crystallization? Urology Research 28(3):167-177.

Salo, R. and D. Cliver. (1978) Inactivation of enteroviruses by ascorbic acid and sodium bisulfite. Applied and Environmental Microbiology 36(l):68-75.

Sandler, J., J. Gallin, and M. Vaughan. (1975) Effects of serotonin, carbamylcholine, and ascorbic acid on leukocyte cyclic GMP and chemotaxis. The Journal of Cell Biology 67(2 Pt l):480-484.

Schwager, J. and J. Schulze. (1997) Influence of ascorbic acid on the response to mitogens and interleukin production of porcine lymphocytes. International Journal for Vitamin and Nutrition Research 67(1):10-16.

Schmahl, D. and G. Eisenbrand. (1982) Influence of ascorbic acid on the endogenous (intragastral) formation of N-nitroso compounds. International Journal for Vitamin and Nutrition Research. Supplement. 23:91-102.

Schropp, J. (1943) Case reports: sulfapyridine sensitivity checked by ascorbic acid. Canadian Medical Association Journal 49:515.

Schvartsman, S. (1983) Vitamin C in the treatment of paediatric intoxications. International Journal for Vitamin and Nutrition Research. Supplement 24:125-129.

Schvartsman, S., S. Zyngier, and C. Schvartsman. (1984) Ascorbic acid and riboflavin in the treatment of acute intoxication by paraquat. Veterinary and Human Toxicology 26(6):473-475.

Scott, J. (1982) On the biochemical similarities of ascorbic acid and interferon. Journal of Theoretical Biology 98(2):235-238.

Senutaite, J. and S. Biziulevicius. (1986) Influence of vitamin C on the resistance of rats to Trichinella spiralis infection. Wiadomosci Parazytologiczne 32(3):261-262.

Sessa, T. (1940) Vitamin C therapy of whooping cough. Riforma Medica 56:38-43.

Shapiro, B., G. Kollman, and J. Asnen. (1965) Ascorbic acid protection against inactivation of lysozyme and aldolase by ionizing radiation. [Technical Report] SAM-TR. USAF School of Aerospace Medicine August, pp. 1-3.

Sharma, D. and R. Mathur. (1995) Correction of anemia and iron deficiency in vegetarians by administration of ascorbic acid. Indian Journal of Physiology and Pharmacology 39(4):403-406.

Shilohi, P. and K. Bhat. (1977) Effect of mega doses of vitamin C on bactericidal activity of leukocytes. The American Journal of Clinical Nutrition 30(7):1077-1081.

Simon, J. and E. Hudes. (1999) Relation of serum ascorbic acid to serum vitamin B12, serum ferritin, and kidney stones in US adults. Archives of Internal Medicine 159(6):619-624.

Simon, J., E. Hudes, and J. Tice. (2001) Relation of serum ascorbic acid to mortality among US adults. Journal of the American College of Nutrition 20(3):255-263.

Singh, P., R. Kiran, A. Pendse, R. Gosh, and S. Surana. (1993) Ascorbic acid is an abettor in calcium urolithiasis: an experimental study. Scanning Microscopy 7(3):1041-1047; discussion 1047-1048.

Shaw, R., M. Holzer, D. Venson, R. Ullman, H. Butcher, and C. Moyer. (1966) A bioassay of treatment of hemorrhagic shock. III. Effects of a saline solution, ascorbic acid, and nicotinamide upon the toxicity of endotoxin for rats. Archives of Surgery 93(4):562-566.

Shi, X., Y. Rojanasakul, P. Gannett, K. Liu, Y. Mao, L. Daniel, N. Ahmed, and U. Saffiotti. (1994) Generation of thiyl and ascorbyl radicals in the reaction of peroxynitrite with thiols and ascorbate at physiological pH. Journal of Inorganic Biochemistry 56(2):77-86.

Shimpo, K., T. Nagatsu, K. Yamada, T. Sato, H. Niimi, M. Shamoto, T. Takeuchi, H. Umezawa, and K. Fujita. (1991) Ascorbic acid and adriamycin toxicity. The American Journal of Clinical Nutrition 54(6 Suppl):1298S-1301S.

Shiraishi, N., H. Uno, and M. Waalkes. (1993) Effect of L-ascorbic acid pretreatment on cadmium toxicity in the male Fischer (F344/NCr) rat. Toxicology 85(2-3):85-100.

Siegel, B. (1974) Enhanced interferon response to murine leukemia virus by ascorbic acid. Infection and Immunity 10(2):409-410.

Siegel, B. (1975) Enhancement of interferon production by poly(rI)-poly(rC) in mouse cell cultures by ascorbic acid. Nature 254(5500): 531-532.

Siegel, B. and J. Morton. (1977) Vitamin C and the immune response. Experientia 33(3):393-395.

Siegel, B. and J. Morton. (1984) Vitamin C and immunity: influence of ascorbate on prostaglandin E2 synthesis and implications for natural killer cell activity. International Journal for Vitamin and Nutrition Research 54(4):339-342.

Sigal, A. and C. King. (1937) The influence of vitamin C deficiency upon the resistance of guinea pigs to diphtheria toxin: glucose tolerance. Journal of Pharmacology and Experimental Therapeutics 61: 1-9.

Simon, J. and E. Hudes. (1999) Relationship of ascorbic acid to blood lead levels. The Journal of the American Medical Association 281(24):2289-2293.

Simon, J., E. Hudes, and J. Tice. (2001) Relation of serum ascorbic acid to mortality among US adults. Journal of the American College of Nutrition 20(3):255-263.

Sippel, H. and O. Forsander. (1974) Non-enzymic oxidation of lower aliphatic alcohols by ascorbic acid in tissue extracts. Acta Chemica Scandinavica. Series B. Organic Chemistry and Biochemistry 28(10):1243-1245.

Sinha, S., S. Gupta, A. Bajaj, P. Singh, and P. Kumar. (1984) A study of blood ascorbic acid in leprosy. International Journal of Leprosy and Other Mycobacterial Diseases 52(2):159-162.

Skinsnes, O. and E. Matsuo. (1976) Hyaluronic acid, 6-glucuronidase, vitamin C and the immune defect in leprosy. International Journal of Dermatology 15(4):286-289.

Slakey, D., A. Roza, G. Pieper, C. Johnson, and M. Adams. (1993a) Ascorbic acid and alpha-tocopherol prolong rat cardiac allograft survival. Transplantation Proceedings 25(1):610-611.

Slotkin, G. and R. Fletcher. (1944) Ascorbic acid in pulmonary complications following prostatic surgery: a preliminary report. Journal of Urology 52:566-569.

Smith, L. (1988) The Clinical Experiences of Frederick R. Klenner, M.D.: Clinical Guide to the Use of Vitamin C. Portland, OR: Life Sciences Press.

Smart, R. and V. Zannoni. (1985) Effect of ascorbate on covalent binding of benzene and phenol metabolites to isolated tissue preparations. Toxicology and Applied Pharmacology 77(2):334-343.

Smart, R. and V. Zannoni. (1986) Effect of dietary ascorbate on covalent binding of benzene to bone marrow and hepatic tissue in vivo. Biochemical Pharmacology 35(18):3180-3182.

Smith, L. (1988) The Clinical Experiences of Frederick R. Klenner, M.D.: Clinical Guide to the Use of Vitamin C. Portland, OR: Life Sciences Press.

Sohler, A., M. Kruesi, and C. Pfeiffer. (1977) Blood lead levels in psychiatrie outpatients reduced by zinc and vitamin C. Journal of Orthomolecular Psychiatry 6(3):272-276.

Soliman, M., A. Elwi, H. El-Kateb, and S. Kamel. (1965) Vitamin C as prophylactic drug against experimental hepatotoxicity. The Journal of the Egyptian Medical Association 48(11):806-812.

Song, B., N. Aebischer, and C. Orvig. (2002) Reduction of [VO2(ma)2]-and [VO2(ema)2]- by ascorbic acid and glutathione: kinetic studies of pro-drugs for the enhancement of insulin action. Inorganic Chemistry 41(6):1357-1364.

Sokolova, V. (1958) Application of vitamin C in treatment of dysentery. Terapevticheskii Arkhiv (Moskva) 30:59-64.

Sprinte, H., C. Parker, G. Smith, and L. Gonzales. (1975) Protective action of ascorbic acid and sulfur compounds against acetaldehyde toxicity: implications in alcoholism and smoking. Agents and Actions 5(2):164-173.

Sprinte, H., C. Parker, and G. Smith. (1979) Comparison of protection by L-ascorbic acid, L-cysteine, and adrenergic-blocking agents against acetaldehyde, acrolein, and formaldehyde toxicity: implications in smoking. Agents and Actions 9(4):407-414.

Sram, R., I. Samkova, and N. Hola. (1983) High-dose ascorbic acid prophylaxis in workers occupationally exposed to halogenated ethers. Journal of Hygiene, Epidemiology, Microbiology, and Immunolog 27(3):305-318.

Steinbach, M. and S. Klein. (1936) Effect of crystalline vitamin C (ascorbic acid) on tolerance to tuberculin. Proceedings of the Society for Experimental Biology and Medicine 35:151-154.

Steinbach, M. and S. Klein. (1941) Vitamin C in experimental tuberculosis. American Review of Tuberculosis 43:403-414.

Stone, I. (1979) Homo sapiens ascorbicus a biochemically corrected robust human mutant. Medical Hypotheses 5(6):711-721.

Stone, I. (1972) The Healing Factor: « Vitamin C » Against Disease. New York, NY: Grosset & Dunlap.

Stone, I. (1980) The possible role of mega-ascorbate in the endogenous synthesis of interferon. Medical Hypotheses 6(3):309-314.

Strangeways, W. (1937) Observations on the trypanocidal action in vitro of solutions of glutathione and ascorbic acid. Armais of Tropical Medicine and Parasitology 31:405-416.

Stoewsand, G., J. Andersen, and C. Lee. (1973) Nitrite-induced methemoglobinemia in guinea pigs: influence of diets concerning beets with varying amounts of nitrate, and the effect of ascorbic acid, and methionine. The Journal of Nutrition 103(3):419-424.

Street, J. and R. Chadwick. (1975) Ascorbic acid requirements and metabolism in relation to organochloride pesticides. Armais of the New York Academy of Sciences 258:132-143.

Sulzberger, M. and B. Oser. (1935) The influence of ascorbic acid in diet on sensitization of guinea pigs to neoarsphenamine. Proceedings of the Society for Experimental Biology and Medicine 32:716.

Sun, F., S. Hayami, Y. Ogiri, S. Haruna, K. Tanaka, Y. Yamada, S. Tokumaru, and S. Kojo. (2000) Evaluation of oxidative stress based on lipid hydroperoxide, vitamin C and vitamin E during apoptosis and necrosis caused by thioacetamide in rat liver. Biochimica et Biophysica Acta 1500(2):181-185.

Suresh, M., J. Lai, S. Kumar, and M. Indira. (1997) Interaction of ethanol and ascorbic acid on lipid metabolism in guinea pigs. Indian Journal of Experimental Biology 35(10):1065-1069.

Suresh, M., J. Lai, C. Sreeranjit Kumar, and M. Indira. (1999) Ascorbic acid metabolism in rats and guinea pigs after the administration of ethanol. Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology 124(2):175-179.

Suresh, M., C. Sreeranjit Kumar, J. Lai, and M. Indira. (1999a) Impact of massive ascorbic acid supplementation on alcohol induced oxidative stress in guinea pigs. Toxicology Letters 104(3):221-229.

Suresh, M., B. Menon, and M. Indira. (2000) Effects of exogenous vitamin C on ethanol toxicity in rats. Indian Journal of Physiology and Pharmacology 44(4):401-410.

Susick, Jr., R. and V. Zannoni. (1984) Ascorbic acid and alcohol oxidation. Biochemical Pharmacology 33(24):3963-3969.

Susick, Jr., R., G. Abrams, C. Zurawski, and V. Zannoni. (1986) Ascorbic acid chronic alcohol consumption in the guinea pig. Toxicology and Applied Pharmacology 84(2):329-335.

Susick, Jr., R. and V. Zannoni. (1987) Effect of ascorbic acid on, the consequences of acute alcohol consumption in humans. Clinical Pharmacology and Therapeutics 41(5)502-509.

Susick, Jr., R. and V. Zannoni. (1987a) Ascorbic acid and elevated SGOT levels after an acute dose of ethanol in the guinea pig. Alcoholism, Clinical and Experimental Research 11(3):265-268.

Suzuki, H., Y. Torii, K. Hitomi, and N. Tsukagoshi. (1993) Ascorbate-dependent elevation of mRNA levels for cytochrome P450s induced by polychlorinated biphenyls. Biochemical Pharmacology 46(1):186-189.

Svirbely, J. (1938) Vitamin C studies in the rat. The effect of selenium dioxide, sodium selenate and tellurate. The Biochemical Journal 32:467-473.

Swartz, R., J. Wesley, M. Somermeyer, and K. Lau. (1984) Hyperoxaluria and renal insufficiency due to ascorbic acid administration during total parenteral nutrition. Annals of Internal Medicine 100(4):530-531.

Sweany, H., C. Clancy, M. Radford, and V. Hunter. (1941) The body economy of vitamin C in health and disease. With special studies in tuberculosis. The Journal of the American Medical Association 116(6):469-474.

Szent-Gyorgyi, A. (1978) How new understandings about the biological function of ascorbic acid may profoundly affect our lives. Executive Health 14(8):l-4.

Szirmai, F. (1940) Value of vitamin C in treatment of acute infectious diseases. Deutsches Archive fur Klinische Medizin 85:434-443.

Tamura, T., H. Inoue, T. lida, and H. Ono. (1969) Studies on the antidotal action of drugs. Part 1. Vitamin C and its antidotal effect against alcoholic and nicotine poisoning. The Journal of Nihon University School of Dentistry 11(4):149-151.

Tamura, T., A. Umezawa, T. lida, and H. Ono. (1970) Studies on the antidotal action of drugs. Part 2. Vitamin C and its antidotal effect against chloroform and carbon tetrachloridum. The Journal of Nihon University School of Dentistry 12(l):25-28.

Taper, H., J. de Gerlache, M. Lans, and M. Roberfroid. (1987) Non-toxic potentiation of cancer chemotherapy by combined C and K3 vitamin pre-treatment. International Journal of Cancer 40(4):575-579.

Tavares, D., A. Cecchi, L. Antunes, and C. Takahashi. (1998) Protective effects of the amino acid glutamine and of ascorbic acid against chromosomal damage induced by doxorubicin in mammalian cells. Teratogenesis, Carcinogenesis, and Mutagenesis 18(4):153-161.

Takenouchi, K., K. Aso, K. Kawase, H. Ichikawa, and T. Shiomi. (1966) On the metabolites of ascorbic acid, especially oxalic acid, eliminated in urine, following the administration of large amounts of ascorbic acid. The Journal of Vitaminology 12(1):49-58.

Tanaka, K., T. Hashimoto, S. Tokumaru, H. Iguchi, and S. Kojo. (1997) Interactions between vitamin C and vitamin E are observed in tissues of inherently scorbutic rats. The Journal of Nutrition 127(10):2060-2064.

Taylor, A., P. Jacques, D. Nadler, F. Morrow, S. Sulsky, and D. Shepard. (1991) Relationship in humans between ascorbic acid consumption and levels of total and reduced ascorbic acid in lens, aqueous humor, and plasma. Current Eye Research 10(8):751-759.

Terezhalmy, G., W. Bottomley, and G. Pelleu. (1978) The use of water-soluble bioflavonoid-ascorbic acid complex in the treatment of recurrent herpes labialis. Oral Surgery, Oral Medicine, Oral Pathology 45(l):56-62.

Thomas, W. and P. Holt. (1978) Vitamin C and immunity: an assessment of the evidence. Clinical and Experimental Immunology 32(2):370-379.

Thorner, R., C. Barker, and R. MacGregor. (1983) Improvement of granulocyte adherence and in vivo granulocyte delivery by ascorbic acid in renal transplant patients. Transplantation 35(5):432-436.

Tiwari, R., S. Bandyopadhyay, and G. Chatterjee. (1982) Protective effect of L-ascorbic acid in lindane intoxicated rats. Acta Vitaminologica et Enzymologica 4(3):215-220.

Tiselius, H. and L. Almgard. (1977) The diurnal urinary excretion of oxalate and the effect of pyridoxine and ascorbate on oxalate excretion. European Urology 3(l):41-46.

Toussant, M. and J. Latshaw. (1994) Evidence of multiple metabolic routes in vanadium’s effects on layers. Ascorbic acid differential effects on prepeak egg production parameters following prolonged vanadium feeding. Poultry Science 73(10):1572-1580.

Treacy, E., L. Arbour, P. Chessex, G. Graham, L. Kasprzak, K. Casey, L. Bell, O. Marner, and C. Scriver. (1996) Glutathione deficiency as a complication of methylmalonic acidemia: response to high doses of ascorbate. The Journal of Pediatrics 129(3):445-448.

Tsao, C. and S. Salimi. (1984) Evidence of rebound effect with ascorbic acid. Medical Hypotheses 13(3):303-310.

Tsao, C., L. Xu, and M. Young. (1990) Effect of dietary ascorbic acid on heat-induced eye lens protein damage in guinea pigs. Ophthalmic Research 22(2):106-110.

Tsugawa, N., T. Yamabe, A. Takeuchi, M. Kamao, K. Nakagawa, K. Nishijima, and T. Okano. (1999) Intestinal absorption of calcium from calcium ascorbate in rats. Journal of Bone and Mineral Metabolism 17(l):30-36.

Tu, B., A. Wallin, P. Moldeus, and I. Cotgreave. (1995) The cytoprotective roles of ascorbate and glutathione against nitrogen dioxide toxicity in human endothelial cells. Toxicology 98(1-3):125-136.

Tuma, D., T. Donohue, Jr., V. Medina, and M. Sorrell. (1984) Enhancement of acetaldehyde-protein adduct formation by L-ascorbate. Archives of Biochemistry and Biophysics 234(2):377-381.

Turner, G. (1964) Inactivation of vaccinia virus by ascorbic acid. Journal of General Microbiology 35:75-80.

Udomratn, T., M. Steinberg, G. Campbell, and F. Oelshlegel. (1977) Effects of ascorbic acid on glucose-6-phosphate dehydrogenase-deficient erythrocytes: studies in an animal model. Blood 49(3):471-475.

Umar, L, A. Wuro-Chekke, A. Gidado, and I. Igbokwe. (1999) Effects of combined parenteral vitamins C and E administration on the severity of anaemia, hepatic and renal damage in Trypanosoma brucei brucei infected rabbits. Veterinary Parasitology 85(l):43-47.

Umegaki, K., S. Aoki, and T. Esashi. (1995) Whole body x-ray irradiation to mice decreases ascorbic acid concentration in bone marrow: comparison between ascorbic acid and vitamin E. Free Radical Biology & Medicine 19(4):493-497.

Upasani, C., A. Khera, and R. Balaraman. (2001) Effect of lead with vitamin E, C, or spirulina on malondialdehyde, conjugated dienes and hydroperoxides in rats. Indian Journal of Experimental Biology 39(l):70-74.

Urivetzky, M., D. Kessaris, and A. Smith. (1992) Ascorbic acid overdosing: a risk factor for calcium oxalate nephrolithiasis. The Journal of Urology 147(5):1215-1218.

Usami, M., H. Tabata, and Y. Ohno. (1999) Effects of ascorbic acid on selenium teratogenicity in cultured rat embryos. Toxicology Letters 105(2):123-128.

Vallance, S. (1977) Relationships between ascorbic acid and serum proteins of the immune system. British Medical Journal 2(6084): 437-438.

Vasil’ev, V. and V. Komar. (1988) [Ascorbic acid level and the indicators of cellular immunity in patients with hepatitis A during pathogenetic therapy]. Article in Russian. Voprosy Pitaniia July-August;(4):31-34.

Vasil’ev, V., V. Komar, and N. Kisel’. (1989) [Humoral and cellular indices of nonspecific resistance in viral hepatitis A and ascorbic acid]. Russian. Terapevticheskii Arkhiv 61(ll):44-46.

Vasavi, H., M. Thangaraju, J. Babu, and P. Sachdanandam. (1998) The salubrious effects of ascorbic acid on cyclophosphamide instigated lipid abnormalities in fibrosarcoma bearing rats. Cancer Biochemistry Biophysics 16(l-2):71-83.

Vatassery, G. (1996) Oxidation of vitamin E, vitamin C, and thiols in rat brain synaptosomes by peroxynitrite. Biochemical Pharmacology 52(4)579-586.

Vauthey, M. (1951) Protective effect of vitamin C against poisons. Praxis (Bern) 40:284-286.

Vermillion, E. and G. Staff ord. (1938) A preliminary report on the use of cevitaminic acid in the treatment of whooping cough. Journal of the Kansas Medical Society 39(11):469,479.

Versteeg, J. (1970) Investigations on the effect of ascorbic acid on antibody production in rabbits after injection of bacterial and viral antigens by different routes. Proceedings of the Koninklijke Nederlandse Akademie van Wetenschappen. Series C. Biological and Medical Sciences 73(5):494-501.

Veselovskaia, T. (1957) Effect of vitamin C on the clinical picture of dysentery. Voenno-Meditsinskii Zhurnal (Moskva) 3:32-37.

Verma, R., R. Shukla, and D. Mehta. (1999) Interaction of aflatoxin with L-ascorbic acid: a kinetic and mechanistic approach. Natural Toxins 7(l):25-29.

Verma, S., I. Tonk, and R. Dalela. (1982) Effects of a few xenobiots on three phosphatases of Saccobranchus fossilis and the role of ascorbic acid in their toxicity. Toxicology Letters 10(2-3):287-292.

Vitorero, J. and J. Doyle. (1938) Treatment of intestinal tuberculosis with vitamin C. Medical Weekly 2:636-640.

Victor, V, N. Guayerbas, M. Puerto, S. Medina, and M. De la Fuente. (2000) Ascorbic acid modulates in vitro the function of macrophages from mice with endotoxic shock. Immunopharmacology 46(1):89-101.

Vij, A., N. Satija, and S. Flora. (1998) Lead induced disorders in hematopoietic and drug metabolizing enzyme System and their protection by ascorbic acid supplementation. Biomedical and Environmental Sciences 11(1):7-14.

Vijayalaxmi, K. and R. Venu. (1999) In vivo anticlastogenic effects of L-ascorbic acid in mice. Mutation Research 438(1):47-51.

Vismara, C., G. Vailati, and R. Bacchetta. (2001) Reduction in paraquat embryotoxicity by ascorbic acid in Xenopus laevis. Aquatic Toxicology 51(3):293-303.

Vogel, R. and H. Spielmann. (1989) Beneficial effects of ascorbic acid on preimplantation mouse embryos after exposure to cyclophosphamide in vivo. Teratogenesis, Carcinogenesis, and Mutagenesis 9(l):51-59.

Von Gagyi, J. (1936) Ueber die bactericide und antitoxische wirkung des vitamin C. Klinische Wochenschrift 15:190-195.

Wagner, B., G. Buettmer, and C. Burns. (1993) Increased generation of lipid-derived and ascorbate free radicals by L1210 cells exposed to the ether lipid edelfosine. Cancer Research 53(4):711-713.

Wagner, B., G. Buettner, and C. Burns. (1994) Free radical-mediated lipid peroxidation in cells: oxidizability is a function of cell lipid bis-allylic hydrogen content. Biochemistry 33(15):4449-4453.

Wahli, T., W. Meier, and K. Pfister. (1986) Ascorbic acid induced immune-mediated decrease in mortality in Ichthyophthirius multifiliis infected rainbow-trout (Salmo gairdneri). Acta Tropica 43(3):287-289.

Wapnick, A., S. Lynch, P. Krawitz, H. Seftel, R. Charlton, and T. Bothwell. (1968) Effects of iron overload on ascorbic acid metabolism. British Medical Journal 3(620):704-707.

Washko, P., Y. Wang, and M. Levine. (1993) Ascorbic acid recycling in human neutrophils. The Journal of Biological Chemistry 268(21):15531-15535.

Wagner, G., R. Carelli, and M. Jarvis. (1985) Pretreatment with ascorbic acid attenuates the neurotoxic effects of methamphetamine in rats. Research Communications in Chemical Pathology and Pharmacology 47(2):221-228.

Wagstaf f, D. and J. Street. (1971) Ascorbic acid deficiency and induction of hepatic microsomal hydroxylative enzymes by organochlorine pesticides. Toxicology and Applied Pharmacology 19(1):10-19.

Warren, F. (1943) Aerobic oxidation of aromatic hydrocarbons in the presence of ascorbic acid. The reaction with anthracene and 3:4-benzpyrene. Biochemical Journal 37:338-341.

Wawrzyniak, A., R. Kieres, and A. Gronowska-Senger. (1997) [The in vitro effect of ascorbic acid on sodium nitrite intoxication]. Article in Polish. Roczniki Panstwowego Zakladu Higieny 48(3):245-252.

Weber, S., J. Thiele, C. Cross, and L. Packer. (1999) Vitamin C, uric acid, and glutathione gradients in murine stratum corneum and their susceptibility to ozone exposure. The Journal of Investigative

Wen, Y., T. Cooke, and J. Feely. (1997) The effect of pharmacological supplementation with vitamin C on low-density lipoprotein oxidation. British Journal of Clinical Pharmacology 44(l):94-97. Dermatology 113(6):1128-1132.

White, L., M. Carpenter, M. Block, A. Basse-Tomusk, T. Gardiner, and G. Rebec. (1988) Ascorbate antagonizes the behavioral effects of amphetamine by a central mechanism. Psychopharmacology 94(2):284-287.

White, L., C. Freeman, B. Forrester, and W. Chappell. (1986) In vitro effect of ascorbic acid on infectivity of herpesviruses and paramyxoviruses. Journal of Clinical Microbiology 24(4)527-531.

Whiteman, M. and B. Halliwell. (1996) Protection against peroxynitrite-dependent tyrosine nitration and alpha 1-antiproteinase inactivation by ascorbic acid. A comparison with other biological antioxidants. Free Radical Research 25(3):275-283.

Wickramasinghe, S. and R. Hasan. (1992) In vitro effects of vitamin C, thioctic acid and dihydrolipoic acid on the cytotoxicity of post-ethanol serum. Biochemical Pharmacology 43(3):407-411.

Wickramasinghe, S. and R. Hasan. (1994) In vivo effects of vitamin C on the cytotoxicity of post-ethanol serum. Biochemical Pharmacology 48(3):621-624.

Wiester, M., J. Tepper, D. Winsett, K. Crissman, J. Richards, and D. Costa. (1996) Adaptation to ozone in rats and its association with ascorbic acid in the lung. Fundamental and Applied Toxicology 31(1): 56-64.

Wilk, I. (1976) Problem-causing constituents of vitamin C tablets. Journal of Chemical Education 53(l):41-43.

Williams, R. and G. Deason. (1967) Individuality in vitamin C needs. Proceedings of the National Academy of Sciences of the United States of America 57(6):1638-1641.

Willette, R., B. Thomas, and G. Barnett. (1983) Inhibition of morphine analgesia by ascorbate. Research Communications in Chemical Pathology and Pharmacology 42(3):485-491.

Wise, J., J. Orenstein, and S. Patierno. (1993) Inhibition of lead chromate clastogenesis by ascorbate: relationship to particle dissolution and uptake. Carcinogenesis 14(3):429-434.

Witt, W., G. Hubbard, and J. Fanton. (1988) Streptococcus pneumoniae arthritis and osteomyelitis with vitamin C deficiency in guinea pigs. Laboratory Animal Science 38(2):192-194.

Wong, K., C. Thomson, R. Bailey, S. McDiarmid, and J. Gardner. (1994) Acute oxalate nephropathy after a massive intravenous dose of vitamin C. Australian and New Zealand Journal of Medicine 24(4):410-411.

Wu, C., T. Dorairajan, and T. Lin. (2000) Effect of ascorbic acid supplementation on the immune response of chickens vaccinated and challenged with infectious bursal disease virus. Veterinary Immunology and Immunopathology 74(1-2):145-152.

Wu, J., K. Karlsson, and A. Danielsson. (1996) Protective effects of trolox C, vitamin C, and catalase on bromobenzene-induced damage to rat hepatocytes. Scandinavian Journal of Gastroenterology 31(8):797-803.

Yamaguchi, T., T. Hashizume, M. Tanaka, M. Nakayama, A. Sugimoto, S. Ikeda, H. Nakajima, and F. Horio. (1997) Bilirubin oxidation provoked by endotoxin treatment is suppressed by feeding ascorbic acid in a rat mutant unable to synthesize ascorbic acid. European Journal of Biochemistry 245(2):233-240.

Yasukawa, M., T. Terasima, and M. Seki. (1989) Radiation-induced neoplastic transformation of C3H10T1/2 cells is suppressed by ascorbic acid. Radiation Research 120(3):456-467.

Yeadon, M. and A. Payne. (1989) Ascorbic acid prevents ozone-induced branchial hyperreactivity in guinea-pigs. British Journal of Pharmacology 98 Suppl:790P.

Yunice, A. and R. Lindeman. (1977) Effect of ascorbic acid and zinc sulfate on ethanol toxicity and metabolism. Proceedings of the Society for Experimental Biology and Medicine 154(1):146-150.

Yunice, A., J. Hsu, A. Fahmy, and S. Henry. (1984) Ethanol-ascorbate interrelationship in acute and chronic alcoholism in the guinea pig. Proceedings of the Society for Experimental Biology and Medicine 177(2):262-271.

Zannoni, V., E. Flynn, and M. Lynch. (1972) Ascorbic acid and drug metabolism. Biochemical Pharmacology 21(10):1377-1392.

Zannoni, V., I Brodfuehrer, R. Smart, and R. Susick, Jr. (1987) Ascorbic acid, alcohol, and environmental chemicals. Annale of the New York Academy of Sciences 498:364-388.

Zaporowska, H. (1994) Effect of vanadium on L-ascorbic acid concentration in rat tissues. General Pharmacology 25(3):467-470.

Zhang, Q., T. Li, H. Zhan, and Y. Xin. (2001) [Inhibitory effects of tea polyphenols and vitamin C on lipid peroxidation induced by FeSO4-cysteine in isolated human plasma and carbon tetrachloride-induced liver free radical injury in mice]. Article in Chinese. Space Medicine & Medical Engineering 14(1)50-53.

Zureick, M. (1950) Treatment of shingles and herpes with vitamin C intravenously. Journal des Praticiens 64:586.